BIP! Finder - A novel in vitro assay reveals SNARE topology and the role of Ykt6 in autophagosome fusion with vacuoles

2018 • A novel in vitro assay reveals SNARE topology and the role of Ykt6 in autophagosome fusion with vacuoles

Authors: Jieqiong Gao; Fulvio Reggiori; Christian Ungermann

Venue: Journal of Cell Biology

Type: Publication

Abstract: Autophagy is a catabolic pathway that delivers intracellular material to the mammalian lysosomes or the yeast and plant vacuoles. The final step in this process is the fusion of autophagosomes with vacuoles, which requires SNARE proteins, the homotypic vacuole fusion and protein sorting tethering complex, the RAB7-like Ypt7 GTPase, and its guanine nucleotide exchange factor, Mon1-Ccz1. Where these different components are located and function during fusion, however, remains to be fully understood. Here, we present a novel in vitro assay to moni... (read more)

Impact:

4.4286896E-8 4.784522E-9 72 46

/ Attention: 0 27

Topics: Cell biology Biochemistry

DOI: 10.1083/jcb.201804039

External links: Crossref OpenAIRE

BibTex PDF

Topic-specific impact indicators

Popularity:
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Influence:
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citation Count:
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Impulse:
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.