BIP! Finder - Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies

2007 • Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies

Authors: Albert P. Li; Edward L. LeCluyse; Gregor Tuschl; Patrick Maurel; J. Gerry Kenna; Jan G. Hengstler; Lena Gustavsson; André Guillouzo; Hayley S. Brown; Maria Jose Gomez Lechon; Nicola J. Hewitt; Christian Skonberg; David Hallifax; Christina Lohmann; J. Brian Houston; Geny M. M. Groothuis

Venue: Drug Metabolism Reviews

Type: Publication

Abstract: This review brings you up-to-date with the hepatocyte research on: 1) in vitro-in vivo correlations of metabolism and clearance; 2) CYP enzyme induction, regulation, and cross-talk using human hepatocytes and hepatocyte-like cell lines; 3) the function and regulation of hepatic transporters and models used to elucidate their role in drug clearance; 4) mechanisms and examples of idiosyncratic and intrinsic hepatotoxicity; and 5) alternative cell systems to primary human hepatocytes. We also report pharmaceutical perspectives of these topics and ... (read more)

Impact:

1.14883484E-7 3.5668123E-8 638 154

/ Attention: 0 96

Topics: Pharmacology Biochemistry Cell biology

DOI: 10.1080/03602530601093489

External links: Crossref OpenAIRE

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