BIP! Finder - Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies

2007 • Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies

Authors: Nicola J. Hewitt, Maria Jose Gomez Lechon, J. Brian Houston, David Hallifax, Hayley S. Brown, Patrick Maurel, J. Gerry Kenna, Lena Gustavsson, Christina Lohmann, Christian Skonberg, André Guillouzo, Gregor Tuschl, Albert P. Li, Edward L. LeCluyse, Geny M. M. Groothuis, Jan G. Hengstler

Venue: Drug Metabolism Reviews

Type: Publication

Abstract: This review brings you up-to-date with the hepatocyte research on: 1) in vitro-in vivo correlations of metabolism and clearance; 2) CYP enzyme induction, regulation, and crosstalk using human hepatocytes and hepatocyte-like cell lines; 3) the function and regulation of hepatic transporters and models used to elucidate their role in drug clearance; 4) mechanisms and examples of idiosyncratic and intrinsic hepatotoxicity; and 5) alternative cell systems to primary human hepatocytes. We also report pharmaceutical perspectives of these topics and c... (read more)

Topics: Pharmacology Biochemistry Cell biology

DOI: 10.1080/03602530601093489

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External links: Crossref OpenAIRE

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