BIP! Finder - Endogenous SNAP-25 Regulates Native Voltage-gated Calcium Channels in Glutamatergic Neurons

2010 • Endogenous SNAP-25 Regulates Native Voltage-gated Calcium Channels in Glutamatergic Neurons

Authors: Condliffe, S. B., Corradini, I., Pozzi, D., Verderio, C., Matteoli, M.

Venue: Journal of Biological Chemistry

Type: Publication

Abstract: In addition to its primary role as a fundamental component of the SNARE complex, SNAP-25 also modulates voltage-gated calcium channels (VGCCs) in various overexpression systems. Although these studies suggest a potential negative regulatory role of SNAP-25 on VGCC activity, the effects of endogenous SNAP-25 on native VGCC function in neurons are unclear. In the present study, we investigated the VGCC properties of cultured glutamatergic and GABAergic rat hippocampal neurons. Glutamatergic currents were dominated by P/Q-type channels, whereas GA... (read more)

Topics: Neuroscience Cell biology

DOI: 10.1074/jbc.m110.145813

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External links: Crossref OpenAIRE

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