Authors: Ellen, Fritsche, Claudia, Schäfer, Christian, Calles, Thorsten, Bernsmann, Bernshausen, Melanie, Wurm, Ulrike, Hübenthal, Jason E, Cline, Hossein, Hajimiragha, Peter, Schroeder, Lars-Oliver, Klotz, Agneta, Rannug, Fürst, Helmut, Hanenberg, Josef, Abel, Jean, Krutmann

Venue: Proceedings of the National Academy of Sciences

Type: Publication

Abstract: UVB radiation-induced signaling in mammalian cells involves two major pathways: one that is initiated through the generation of DNA photoproducts in the nucleus and a second one that occurs independently of DNA damage and is characterized by cell surface receptor activation. The chromophore for the latter one has been unknown. Here, we report that the UVB response involves tryptophan as a chromophore. We show that through the intracellular generation of photoproducts, such as the arylhydrocarbon receptor (AhR) ligand 6-formylindolo[3,2- b ]carb... (read more)

DOI: 10.1073/pnas.0701764104