BIP! Finder - TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum

2005 • TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum

Authors: Gerco HASSINK, Marjolein KIKKERT, Sjaak van VOORDEN, Shiow-Ju LEE, Robbert SPAAPEN, Theo van LAAR, Catherine S. COLEMAN, Eric BARTEE, Klaus FRÜH, Vincent CHAU, Emmanuel WIERTZ

Venue: Biochemical Journal

Type: Article

Abstract: In the present study, the human TEB4 is identified as a novel ER (endoplasmic reticulum)-resident ubiquitin ligase. TEB4 has homologues in many species and has a number of remarkable properties. TEB4 contains a conserved RING (really interesting new gene) finger and 13 predicted transmembrane domains. The RING finger of TEB4 and its homologues is situated at the N-terminus and has the unconventional C4HC3 configuration. The N-terminus of TEB4 is located in the cytosol. We show that the isolated TEB4 RING domain catalyses ubiquitin ligation in v... (read more)

Topics: Cell biology Biochemistry

DOI: 10.1042/bj20041241

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External links: Crossref , OpenAIRE

References (60) Citations (139) BibTex PDF

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