BIP! Finder - A replication study of genetic risk loci for ischemic stroke in a Dutch population: a case-control study

2017 • A replication study of genetic risk loci for ischemic stroke in a Dutch population: a case-control study

Authors: Hauer, Allard J.; Pulit, Sara L.; Van Den Berg, Leonard H.; De Bakker, Paul I.W.; Veldink, Jan H.; Ruigrok, Ynte M.; Klijn, Catharina J.M.; Algra, Ale; Van Dijk, Ewoud J.; Koudstaal, Peter J.; Luijckx, Gert Jan; Nederkoorn, Paul J.; Van Oostenbrugge, Robert J.; Visser, Marieke C.; Wermer, Marieke J.; Kappelle, L. Jaap

Venue: Scientific Reports

Type: Publication

Abstract: AbstractWe aimed to replicate reported associations of 10 SNPs at eight distinct loci with overall ischemic stroke (IS) and its subtypes in an independent cohort of Dutch IS patients. We included 1,375 IS patients enrolled in a prospective multicenter hospital-based cohort in the Netherlands, and 1,533 population-level controls of Dutch descent. We tested these SNPs for association with overall IS and its subtypes (large artery atherosclerosis, small vessel disease and cardioembolic stroke (CE), as classified by TOAST) using an additive multiva... (read more)

Impact:

7.37782E-9 3.5418732E-9 9 3

/ Attention: 0 17

Topics: Internal medicine Oncology Bioinformatics

DOI: 10.1038/s41598-017-07404-4

External links: Crossref OpenAIRE

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