BIP! Finder - Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12

2011 • Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12

Authors: Nahuai Badiola, Clara Penas, Alfredo J. Miñano-Molina, B Barneda-Zahonero, Rut Fadó, G Sánchez-Opazo, Joan X. Comella, Josefa Sabrià, Changlian Zhu, Klas Blomgren, Caty Casas, José Rodríguez-Alvarez

Venue: Cell Death & Disease

Type: Publication

Abstract: Disturbance of calcium homeostasis and accumulation of misfolded proteins in the endoplasmic reticulum (ER) are considered contributory components of cell death after ischemia. However, the signal-transducing events that are activated by ER stress after cerebral ischemia are incompletely understood. In this study, we show that caspase-12 and the PERK and IRE pathways are activated following oxygen-glucose deprivation (OGD) of mixed cortical cultures or neonatal hypoxia–ischemia (HI). Activation of PERK led to a transient phosphorylation of eI... (read more)

Topics: Cell biology

DOI: 10.1038/cddis.2011.31

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