Authors: Teruel, María; Barturen, Guillermo; Martínez Bueno, Manuel; Castellini Pérez, Olivia; Barroso Gil, Miguel; Povedano, Elena; Kerick, Martin; Català Moll, Francesc; Makowska, Zuzanna; Buttgereit, Anne; Beretta, Lorenzo; Chizzolini, Carlo; Zuber, Aleksandra; Wynar, Donatienne; Kovács, Laszló; Balog, Attila; Deák, Magdolna; Bocskai, Márta; Dulic, Sonja; Kádár, Gabriella; Hiepe, Falk; Gerl, Velia; Thiel, Silvia; Rodriguez Maresca, Manuel; López Berrio, Antonio; Aguilar Quesada, Rocío; Navarro Linares, Héctor; Alvarez, Montserrat; Álvarez Errico, Damiana; Azevedo, Nancy; Barbarroja, Nuria; Cheng, Qingyu; Cremer, Jonathan; Groof, Aurélie de; Langhe, Ellen de; Ducreux, Julie; Dufour, Aleksandra; Hernández Fuentes, María; Khodadadi, Laleh; Kniesch, Katja; Li, Tianlu; López Pedrera, Chary; Marañón, Concepción; Muchmore, Brian; Neves, Esmeralda; Rouvière, Bénédicte; Simon, Quentin; Trombetta, Elena; Varela, Nieves; Witte, Torsten; Pers, Jacques-olivier; Ballestar, Esteban; Martin, Javier; Carnero Montoro, Elena; Alarcón Riquelme, Marta; Precisesads Clinical Consortium; Precisesads Flow Cytometry Study Group; Vigone, Barbara; Pers, Jacques Olivier; Saraux, Alain; Devauchelle-Pensec, Valérie; Cornec, Divi; Jousse-Joulin, Sandrine; Lauwerys, Bernard; Maudoux, Anne-lise; Vasconcelos, Carlos; Tavares, Ana; Faria, Raquel; Brandão, Mariana; Campar, Ana; Marinho, António; Farinha, Fátima; Almeida, Isabel; Gonzalez-Gay Mantecón, Miguel Ángel; Blanco Alonso, Ricardo; Corrales Martínez, Alfonso; Cervera, Ricard; Rodríguez Pintó, Ignasi; Espinosa, Gerard; Lories, Rik; Hunzelmann, Nicolas; Belz, Doreen; Baerlecken, Niklas; Stummvoll, Georg; Zauner, Michael; Lehner, Michaela; Collantes, Eduardo; Ortega Castro, Rafaela; Aguirre Zamorano, Mª Angeles; Escudero Contreras, Alejandro; Castro Villegas, Mª Carmen; Ortego, Norberto; Fernández Roldán, María Concepción; Raya, Enrique; Jiménez Moleón, Inmaculada; Ramon, Enrique de; Díaz Quintero, Isabel; Meroni, Pier Luigi; Gerosa, Maria; Schioppo, Tommaso; Artusi, Carolina

Venue: Scientific Reports

Type: Publication

Abstract: AbstractPrimary Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by lymphocytic infiltration and damage of exocrine salivary and lacrimal glands. The etiology of SS is complex with environmental triggers and genetic factors involved. By conducting an integrated multi-omics study, we confirmed a vast coordinated hypomethylation and overexpression effects in IFN-related genes, what is known as the IFN signature. Stratified and conditional analyses suggest a strong interaction between SS-associatedHLAgenetic variation and ... (read more)

DOI: 10.1038/s41598-021-01324-0