BIP! Finder - Rainbow trout exposed to benzo[a]pyrene yields conserved microRNA binding sites in DNA methyltransferases across 500 million years of evolution

2017 • Rainbow trout exposed to benzo[a]pyrene yields conserved microRNA binding sites in DNA methyltransferases across 500 million years of evolution

Authors: Andrew C. Doxey; Christopher Kuc; Mark R. Servos; Paul M. Craig; Leslie M. Bragg; Samantha Johnson; Daniel Richard

Venue: Scientific Reports

Type: Publication

Abstract: AbstractThe objective of this study was to examine the regulation of DNA methylation following acute (24 h) and prolonged (14 d) exposure to low (1 ng/L) and high (10 ng/L) benzo[a]pyrene. However, with the recent release of the rainbow trout genome, we were able to conduct a more detailed analysis regarding the regulation of the enzymes involved in DNA methylation; DNA methyltransferases (DNMTs). Bioinformatic approaches were used to identify candidate microRNA (miRNA) that potentially bind to the DNMT1 and DNMT3a 3′UTR. Results indicated a ... (read more)

Impact:

1.1421701E-8 3.1546936E-9 18 8

/ Attention: 0 21

Topics: Genetics

DOI: 10.1038/s41598-017-17236-x

External links: Crossref OpenAIRE

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