BIP! Finder - ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments

2017 • ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments

Authors: Wu, Yu; Pons, Valérie; Goudet, Amélie; Panigai, Laetitia; Fischer, Annette; Herweg, Jo-Ana; Kali, Sabrina; Davey, Robert A; Laporte, Jérôme; Bouclier, Céline; Yousfi, Rahima; Aubenque, Céline; Merer, Goulven; Gobbo, Emilie; Lopez, Roman; Gillet, Cynthia; Cojean, Sandrine; Popoff, Michel R; Clayette, Pascal; Le Grand, Roger; Boulogne, Claire; Tordo, Noël; Lemichez, Emmanuel; Loiseau, Philippe M; Rudel, Thomas; Sauvaire, Didier; Cintrat, Jean-Christophe; Gillet, Daniel; Barbier, Julien

Venue: Scientific Reports

Type: Publication

Abstract: AbstractIntracellular pathogenic microorganisms and toxins exploit host cell mechanisms to enter, exert their deleterious effects as well as hijack host nutrition for their development. A potential approach to treat multiple pathogen infections and that should not induce drug resistance is the use of small molecules that target host components. We identified the compound 1-adamantyl (5-bromo-2-methoxybenzyl) amine (ABMA) from a cell-based high throughput screening for its capacity to protect human cells and mice against ricin toxin without toxi... (read more)

Impact:

1.2433072E-8 3.045778E-9 16 4

/ Attention: 0 106

Topics: Cell biology Microbiology

DOI: 10.1038/s41598-017-15466-7

External links: Crossref OpenAIRE

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