Authors: Wu, Yu, Pons, Valérie, Goudet, Amélie, Panigai, Laetitia, Fischer, Annette, Herweg, Jo-Ana, Kali, Sabrina, Davey, Robert A., Laporte, Jérôme, Bouclier, Céline, Yousfi, Rahima, Aubenque, Merer, Goulven, Gobbo, Emilie, Lopez, Roman, Gillet, Cynthia, Cojean, Sandrine, Popoff, Michel R., Clayette, Pascal, Le Grand, Roger, Boulogne, Claire, Tordo, Noël, Lemichez, Emmanuel, Loiseau, Philippe M., Rudel, Thomas, Sauvaire, Didier, Cintrat, Jean-Christophe, Daniel, Barbier, Julien
Venue: Scientific Reports
Type: Publication
Abstract: AbstractIntracellular pathogenic microorganisms and toxins exploit host cell mechanisms to enter, exert their deleterious effects as well as hijack host nutrition for their development. A potential approach to treat multiple pathogen infections and that should not induce drug resistance is the use of small molecules that target host components. We identified the compound 1-adamantyl (5-bromo-2-methoxybenzyl) amine (ABMA) from a cell-based high throughput screening for its capacity to protect human cells and mice against ricin toxin without toxi...
(read more)
Topics: 
Cell biology
Microbiology
Loading (it may take a couple of seconds)...
Loading (it may take a couple of seconds)...