Authors: Jorge, Errecalde, Adrian, Lifschitz, Graciela, Vecchioli, Laura, Ceballos, Francisco, Mariana, Ballent, Gustavo, Marín, Martín, Daniele, Esteban, Turic, Eduardo, Spitzer, Fernando, Toneguzzo, Silvia, Gold, Alejandro, Krolewiecki, Luis, Alvarez, Carlos, Lanusse
Venue: Journal of Pharmaceutical Sciences
Type: Publication
Abstract: Recently published data indicates that high ivermectin (IVM) concentrations suppress in vitro SARS-CoV-2 replication. Nasal IVM spray administration may contribute to attaining high drug concentrations in nasopharyngeal tissue, a primary site of virus entrance/replication. The safety and pharmacokinetic performances of a novel IVM spray formulation were assessed in a pig model. Piglets received IVM either orally (0.2 mg/kg) or by one or two nasal spray doses. The overall safety, and histopathology of the IVM-spray application site tissues, were...
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Topics: 
Pharmacology
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