BIP! Finder - An adverse outcome pathway on the disruption of retinoic acid metabolism leading to developmental craniofacial defects

2021 • An adverse outcome pathway on the disruption of retinoic acid metabolism leading to developmental craniofacial defects

Authors: Elena Menegola; Christina H.J. Veltman; Maria Battistoni; Francesca Di Renzo; Angelo Moretto; Francesca Metruccio; Anna Beronius; Johanna Zilliacus; Katerina Kyriakopoulou; Anastasia Spyropoulou; Kyriaki Machera; Leo T.M. van der Ven; Mirjam Luijten

Venue: Toxicology

Type: Publication

Abstract: Adverse outcome pathway (AOP) is a conceptual framework that links a molecular initiating event (MIE) via intermediate key events (KEs) with adverse effects (adverse outcomes, AO) relevant for risk assessment, through defined KE relationships (KERs). The aim of the present work is to describe a linear AOP, supported by experimental data, for skeletal craniofacial defects as the AO. This AO was selected in view of its relative high incidence in humans and the suspected relation to chemical exposure. We focused on inhibition of CYP26, a retinoic ... (read more)

Impact:

1.5937943E-8 3.5295455E-9 16 14

/ Attention: 0 20

Topics: Bioinformatics

DOI: 10.1016/j.tox.2021.152843

External links: Crossref OpenAIRE

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