Abstract: Abstract Synthetic derivative of C-terminal fragment of CART (55–102) with reduced thiol groups, [Abu 86,94 ]CART (85–102) red , given together with amphetamine (5 mg/kg, s.c.) or cocaine (15 mg/kg, s.c.), reversed hyperlocomotion induced by these drugs at a dose of 0.1 μg but not at a higher dose. In the cerebral cortex homogenate, [Abu 86,94 ]CART (85–102) red was nonspecifically cleaved from N- and C-termini. This peptide contains two chemically blocked Cys residues, and two others in reduced form. Concomitant with cleavage, rapid cyc...
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Topics: 
Stereochemistry
Pharmacology
Biochemistry