BIP! Finder - XRCC1 prevents toxic PARP1 trapping during DNA base excision repair

2021 • XRCC1 prevents toxic PARP1 trapping during DNA base excision repair

Authors: Richard Hailstone; Kouji Hirota; Shunichi Takeda; Ilona Kalasova; Keith W. Caldecott; Marek Adamowicz; William Gittens; Jan Brazina; Zhengping Shao; Masataka Tsuda; Annie A. Demin; Hana Hanzlikova; Hiroyuki Sasanuma; Shan Zha

Venue: Molecular Cell

Type: Publication

Abstract: Mammalian DNA base excision repair (BER) is accelerated by poly(ADP-ribose) polymerases (PARPs) and the scaffold protein XRCC1. PARPs are sensors that detect single-strand break intermediates, but the critical role of XRCC1 during BER is unknown. Here, we show that protein complexes containing DNA polymerase β and DNA ligase III that are assembled by XRCC1 prevent excessive engagement and activity of PARP1 during BER. As a result, PARP1 becomes "trapped" on BER intermediates in XRCC1-deficient cells in a manner similar to that induced by PARP ... (read more)

Impact:

1.1670369E-7 5.1162004E-9 120 116

/ Attention: 0 14

Topics: Molecular biology Cell biology

DOI: 10.1016/j.molcel.2021.05.009

External links: Crossref OpenAIRE

BibTex PDF

Topic-specific impact indicators

Popularity:
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Influence:
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citation Count:
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Impulse:
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.