BIP! Finder - RNA Recognition and Cleavage by the SARS Coronavirus Endoribonuclease

2006 • RNA Recognition and Cleavage by the SARS Coronavirus Endoribonuclease

Authors: Jingchuan Sun; Kanchan Bhardwaj; C. Cheng Kao; Linda A. Guarino; Andreas Holzenburg

Venue: Journal of Molecular Biology

Type: Publication

Abstract: The emerging disease SARS is caused by a novel coronavirus that encodes several unusual RNA-processing enzymes, including non-structural protein 15 (Nsp15), a hexameric endoribonuclease that preferentially cleaves at uridine residues. How Nsp15 recognizes and cleaves RNA is not well understood and is the subject of this study. Based on the analysis of RNA products separated by denaturing gel electrophoresis, Nsp15 has been reported to cleave both 5' and 3' of the uridine. We used several RNAs, including some with nucleotide analogs, and mass sp... (read more)

Impact:

7.2528E-8 1.0098599E-8 121 17

/ Attention: 0 34

Topics: Virology

DOI: 10.1016/j.jmb.2006.06.021

External links: Crossref OpenAIRE

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