BIP! Finder - Global Research Expedition on Altitude-related Chronic Health 2018 Iron Infusion at High Altitude Reduces Hypoxic Pulmonary Vasoconstriction Equally in Both Lowlanders and Healthy Andean Highlanders

2022 • Global Research Expedition on Altitude-related Chronic Health 2018 Iron Infusion at High Altitude Reduces Hypoxic Pulmonary Vasoconstriction Equally in Both Lowlanders and Healthy Andean Highlanders

Authors: James D. Anholm; Damian M. Bailey; Connor A. Howe; John D. Akins; Travis D. Gibbons; Michael M. Tymko; Rachel Stone; Joshua C. Tremblay; Tony G. Dawkins; Kaitlyn Tymko; Christopher Gasho; Ryan L. Hoiland; Alexander Patrician; Philip N. Ainslie; Francisco C. Villafuerte; Geoff B. Coombs; Rómulo Figueroa-Mujíca; Mike Stembridge; Courtney Tymko; Benjamin S. Stacey; Gustavo Vizcardo-Galindo

Venue: Chest

Type: Publication

Abstract: Increasing iron bioavailability attenuates hypoxic pulmonary vasoconstriction in both lowlanders and Sherpas at high altitude. In contrast, the pulmonary vasculature of Andean individuals with chronic mountain sickness (CMS) is resistant to iron administration. Although pulmonary vascular remodeling and hypertension are characteristic features of CMS, the effect of iron administration in healthy Andean individuals, to our knowledge, has not been investigated. If the interplay between iron status and pulmonary vascular tone in healthy Andean ind... (read more)

Impact:

1.2191929E-8 3.2534015E-9 10 10

/ Attention: 0 35

Topics: Internal medicine Anesthesia Cardiology

DOI: 10.1016/j.chest.2021.08.075

External links: Crossref OpenAIRE

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