BIP! Finder - Host-directed editing of the SARS-CoV-2 genome

2021 • Host-directed editing of the SARS-CoV-2 genome

Authors: Arnab Pain; Mukhtar Sadykov; Gabriel Gonzalez; Tobias Mourier; Michael J. Carr; William W. Hall

Venue: Biochemical and Biophysical Research Communications

Type: Publication

Abstract: The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In this brief review we describe three such human defense mechanisms, the apolipoprotein B mRNA editing catalytic polypeptide-like proteins (APOBEC), adenosine deaminase acting on RNA proteins (ADAR), and reactive oxygen species (ROS), and discuss their p... (read more)

Impact:

8.610751E-8 5.2795786E-9 83 83

/ Attention: 0 24

Topics: Genetics Virology Computational biology

DOI: 10.1016/j.bbrc.2020.10.092

External links: Crossref OpenAIRE

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