BIP! Finder - Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial

2015 • Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial

Authors: Harry, Bartelink, Philippe, Maingon, Philip, Poortmans, Caroline, Weltens, Alain, Fourquet, Jos, Jager, Dominic, Schinagl, Bing, Oei, Carla, Rodenhuis, Jean-Claude, Horiot, Henk, Struikmans, Erik, Van Limbergen, Youlia, Kirova, Paula, Elkhuizen, Rudolf, Bongartz, Raymond, Miralbell, David, Morgan, Jean-Bernard, Dubois, Vincent, Remouchamps, René-Olivier, Mirimanoff, Sandra, Collette, Laurence, F, Kovner

Venue: The Lancet Oncology

Type: Publication

Abstract: BACKGROUND: Since the introduction of breast-conserving treatment, various radiation doses after lumpectomy have been used. In a phase 3 randomised controlled trial, we investigated the effect of a radiation boost of 16 Gy on overall survival, local control, and fibrosis for patients with stage I and II breast cancer who underwent breast-conserving treatment compared with patients who received no boost. Here, we present the 20-year follow-up results. METHODS: Patients with microscopically complete excision for invasive disease followed by whole... (read more)

Topics: Surgery Internal medicine

DOI: 10.1016/s1470-2045(14)71156-8

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