BIP! Finder - Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial

2015 • Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial

Authors: Bartelink, Harry; Maingon, Philippe; Poortmans, Philip; Weltens, Caroline; Fourquet, Alain; Jager, Jos; Schinagl, Dominic; Oei, Bing; Rodenhuis, Carla; Horiot, Jean-Claude; Struikmans, Henk; Van Limbergen, Erik; Kirova, Youlia; Elkhuizen, Paula; Bongartz, Rudolf; Miralbell, Raymond; Morgan, David; Dubois, Jean-Bernard; Remouchamps, Vincent; Mirimanoff, René-Olivier; Collette, Sandra; Collette, Laurence

Venue: The Lancet Oncology

Type: Publication

Abstract: Since the introduction of breast-conserving treatment, various radiation doses after lumpectomy have been used. In a phase 3 randomised controlled trial, we investigated the effect of a radiation boost of 16 Gy on overall survival, local control, and fibrosis for patients with stage I and II breast cancer who underwent breast-conserving treatment compared with patients who received no boost. Here, we present the 20-year follow-up results.Patients with microscopically complete excision for invasive disease followed by whole-breast irradiation of... (read more)

Impact: 1.7229233E-7 2.2750823E-8 387 89 / Attention: 0 122

Topics: Breast Cancer Treatment Studies Breast Lesions and Carcinomas Breast Implant and Reconstruction

DOI: 10.1016/s1470-2045(14)71156-8

External links: Crossref OpenAIRE

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