BIP! Finder - PR-Set7 Is a Nucleosome-Specific Methyltransferase that Modifies Lysine 20 of Histone H4 and Is Associated with Silent Chromatin

2002 • PR-Set7 Is a Nucleosome-Specific Methyltransferase that Modifies Lysine 20 of Histone H4 and Is Associated with Silent Chromatin

Authors: Kenichi, Nishioka, Judd C, Rice, Kavitha, Sarma, Hediye, Erdjument-Bromage, Janis, Werner, Yanming, Wang, Sergei, Chuikov, Pablo, Valenzuela, Paul, Tempst, Ruth, Steward, John T, Lis, C David, Allis, Danny, Reinberg

Venue: Molecular Cell

Type: Publication

Abstract: We have purified a human histone H4 lysine 20 methyltransferase and cloned the encoding gene, PR/SET07. A mutation in Drosophila pr-set7 is lethal: second instar larval death coincides with the loss of H4 lysine 20 methylation, indicating a fundamental role for PR-Set7 in development. Transcriptionally competent regions lack H4 lysine 20 methylation, but the modification coincided with condensed chromosomal regions on polytene chromosomes, including chromocenter and euchromatic arms. The Drosophila male X chromosome, which is hyperacetylated at... (read more)

Topics: Molecular biology Genetics

DOI: 10.1016/s1097-2765(02)00548-8

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External links: Crossref OpenAIRE

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