BIP! Finder - Mitotic Phosphorylation of Histone H3 Is Governed by Ipl1/aurora Kinase and Glc7/PP1 Phosphatase in Budding Yeast and Nematodes

2000 • Mitotic Phosphorylation of Histone H3 Is Governed by Ipl1/aurora Kinase and Glc7/PP1 Phosphatase in Budding Yeast and Nematodes

Authors: Hsu, Jer-Yuan, Sun, Zu-Wen, Li, Xiumin, Reuben, Melanie, Tatchell, Kelly, Bishop, Douglas K, Grushcow, Jeremy M, Brame, Cynthia J, Caldwell, Jennifer A, Hunt, Donald F, Lin, Rueyling, Smith, M.Mitchell, Allis, C.David

Venue: Cell

Type: Publication

Abstract: AbstractPhosphorylation of histone H3 at serine 10 occurs during mitosis and meiosis in a wide range of eukaryotes and has been shown to be required for proper chromosome transmission in Tetrahymena. Here we report that Ipl1/aurora kinase and its genetically interacting phosphatase, Glc7/PP1, are responsible for the balance of H3 phosphorylation during mitosis in Saccharomyces cerevisiae and Caenorhabditis elegans. In these models, both enzymes are required for H3 phosphorylation and chromosome segregation, although a causal link between the tw... (read more)

Topics: Cell biology Genetics

DOI: 10.1016/s0092-8674(00)00034-9

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External links: Crossref OpenAIRE

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