BIP! Finder - Mitotic Phosphorylation of Histone H3 Is Governed by Ipl1/aurora Kinase and Glc7/PP1 Phosphatase in Budding Yeast and Nematodes

2000 • Mitotic Phosphorylation of Histone H3 Is Governed by Ipl1/aurora Kinase and Glc7/PP1 Phosphatase in Budding Yeast and Nematodes

Authors: Kelly Tatchell; Zu-Wen Sun; M. Mitchell Smith; Melanie Reuben; Xiumin Li; C. David Allis; Jer-Yuan Hsu; Jennifer A. Caldwell; Jeremy M. Grushcow; Cynthia J. Brame; Rueyling Lin; Douglas K. Bishop; Donald F. Hunt

Venue: Cell

Type: Publication

Abstract: Phosphorylation of histone H3 at serine 10 occurs during mitosis and meiosis in a wide range of eukaryotes and has been shown to be required for proper chromosome transmission in Tetrahymena. Here we report that Ipl1/aurora kinase and its genetically interacting phosphatase, Glc7/PP1, are responsible for the balance of H3 phosphorylation during mitosis in Saccharomyces cerevisiae and Caenorhabditis elegans. In these models, both enzymes are required for H3 phosphorylation and chromosome segregation, although a causal link between the two proces... (read more)

Impact:

9.001009E-8 6.096169E-8 757 161

/ Attention: 0 39

Topics: Cell biology Genetics

DOI: 10.1016/s0092-8674(00)00034-9

External links: Crossref OpenAIRE

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