BIP! Finder - Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation.

1994 • Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation.

Authors: Jakob Troppmair, Joseph T. Bruder, H. Munoz, Patricia Lloyd, John M. Kyriakis, Papia Banerjee, Joseph Avruch, Ulf R. Rapp

Venue: Journal of Biological Chemistry

Type: Publication

Abstract: The protein kinase cascade Raf-MAPKK/MEK-MAPK/ERK connects protein tyrosine kinase receptors in the membrane with control of transcription factor activity in the nucleus. We have examined whether Raf is obligatory for activation of this cascade and whether this signaling pathway is relevant to transformation. By use of transient assays with epitope-tagged ERK-1 cDNA and a dominant inhibitory mutant of Raf-1 we found that serum and 12-O-tetradecanoylphorbol-13-acetate as well as representatives of three classes of oncogenes (protein tyrosine kin... (read more)

Topics: Cell biology Molecular biology Biochemistry

DOI: 10.1016/s0021-9258(17)37478-1

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