BIP! Finder - Estrogenic effects associated with bisphenol a exposure in male zebrafish (Danio rerio) is associated with changes of endogenous 17β-estradiol and gene specific DNA methylation levels

2017 • Estrogenic effects associated with bisphenol a exposure in male zebrafish (Danio rerio) is associated with changes of endogenous 17β-estradiol and gene specific DNA methylation levels

Authors: Fei, Zhao, Penghao, Wei, Jun, Wang, Miao, Yu, Xiaona, Zhang, Hua, Tian, Shaoguo, Ru

Venue: General and Comparative Endocrinology

Type: Publication

Abstract: The binding affinity of bisphenol A (BPA) to estrogen receptors (ERs) is much lower than that of 17β-estradiol (E2), and whether there are other molecular mechanisms responsible for the estrogenic action of BPA in vivo currently remains unknown. The objective of this study was to explore the potential association between the estrogenic effect induced by bisphenol A in vivo and changes of endogenous E2 and gene specific DNA methylation levels. After a waterborne exposure of male zebrafish to 500, 1000, or 1500μg/L of BPA for 21d, vitellogenin ... (read more)

Topics: Internal medicine Endocrinology

DOI: 10.1016/j.ygcen.2017.07.032

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External links: Crossref OpenAIRE

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