Authors: Gavin, Maxwell, Cameron, MacKay, Richard, Cubberley, Michael, Davies, Nichola, Gellatly, Stephen, Glavin, Todd, Gouin, Sandrine, Jacquoilleot, Craig, Moore, Ruth, Pendlington, Ouarda, Saib, David, Sheffield, Stark, Vicki, Summerfield
Venue: Toxicology in Vitro
Type: Publication
Abstract: As documented in the recent OECD report 'the adverse outcome pathway for skin sensitisation initiated by covalent binding to proteins' (OECD, 2012), the chemical and biological events driving the induction of human skin sensitisation have been investigated for many years and are now well understood. Several non-animal test methods have been developed to predict sensitiser potential by measuring the impact of chemical sensitisers on these key events (Adler et al., 2011; Maxwell et al., 2011); however our ability to use these non-animal datasets ...
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Topics: 
Computational biology
Toxicology
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