Authors: Schroeder, K., Bremm, K.D., Alépée, N., Bessems, J.G.M., Blaauboer, B., Boehn, S.N., Burek, C., Coecke, S., Gombau, L., Hewitt, N.J., Heylings, J., Huwyler, Jaeger, M., Jagelavicius, Jarrett, Ketelslegers, H., Kocina, I., Koester, Kreysa, Note, R., Poth, A., Radtke, Rogiers, V., Scheel, Schulz, T., Steinkellner, Toeroek, Whelan, Winkler, P., Diembeck, W.
Venue: Toxicology in Vitro
Type: Publication
Abstract: AbstractThere are now numerous in vitro and in silico ADME alternatives to in vivo assays but how do different industries incorporate them into their decision tree approaches for risk assessment, bearing in mind that the chemicals tested are intended for widely varying purposes? The extent of the use of animal tests is mainly driven by regulations or by the lack of a suitable in vitro model. Therefore, what considerations are needed for alternative models and how can they be improved so that they can be used as part of the risk assessment proce...
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Topics: 
Risk analysis (engineering)
Biochemical engineering
Biotechnology
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