BIP! Finder - Use of IL-18 production in a human keratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory allergens

2009 • Use of IL-18 production in a human keratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory allergens

Authors: Emanuela, Corsini, Montserrat, Mitjans, Valentina, Galbiati, Laura, Lucchi, Corrado L, Galli, Marina, Marinovich

Venue: Toxicology in Vitro

Type: Publication

Abstract: Assessment of allergenic potential of chemicals is performed using animal models, such as the murine local lymph node assay, which does not distinguish between respiratory and contact allergens. Progress in understanding the mechanisms of skin sensitization, provides us with the opportunity to develop in vitro tests as an alternative to in vivo sensitization testing. The aim of the present study was to evaluate the possibility to use intracellular interleukin-18 (IL-18) production to assess in vitro the contact sensitization potential of low mo... (read more)

Topics: Immunology Pharmacology

DOI: 10.1016/j.tiv.2009.04.005

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