BIP! Finder - Differential susceptibilities of Holtzman and Sprague–Dawley rats to fetal death and placental dysfunction induced by 2,3,7,8-teterachlorodibenzo-p-dioxin (TCDD) despite the identical primary structure of the aryl hydrocarbon receptor

2006 • Differential susceptibilities of Holtzman and Sprague–Dawley rats to fetal death and placental dysfunction induced by 2,3,7,8-teterachlorodibenzo-p-dioxin (TCDD) despite the identical primary structure of the aryl hydrocarbon receptor

Authors: Takashige Kawakami, Ryuta Ishimura, Keiko Nohara, Ken Takeda, Chiharu Tohyama, Seiichiroh Ohsako

Venue: Toxicology and Applied Pharmacology

Type: Publication

Abstract: A single oral dose of 2,3,7,8-tetrachlorodibenzo-p-dioin (TCDD) administered to pregnant Holtzman (HLZ) rats on gestational days 15 (GD15) caused placental dysfunction, resulting in fetal death (Ishimura, R., Ohsako, S., Miyabara, Y., Sakaue, M., Kawakami, T., Aoki, Y., Yonemoto, J., Tohyama, C., 2002a. Increased glycogen content and glucose transporter 3 mRNA level in the placenta of Holtzman rats after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol. Appl. Pharmacol. 178, 161-171; Ishimura, R., Ohsako, S., Kawakami, T., Sakaue, M., A... (read more)

Topics: Internal medicine Endocrinology Andrology

DOI: 10.1016/j.taap.2005.08.007

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