Authors: H, Witters, A, Freyberger, K, Smits, C, Vangenechten, W, Lofink, M, Weimer, S, Bremer, P H-J, Ahr, P, Berckmans

Venue: Reproductive Toxicology

Type: Publication

Abstract: The need for development and validation of in vitro hormone receptor transactivation assays as important alternative tools to study interactions with sex hormone receptors is outlined by international organisations, as such assays should be included in the OECD conceptual framework for the testing and assessment of endocrine active chemicals. Therefore as part of the European Union (EU)-sponsored 6th framework project ReProTect, the validation study with MELN cells, MCF-7 cells which were stably transfected with the estrogen responsive gene ERE... (read more)

DOI: 10.1016/j.reprotox.2010.02.008