Authors: Herdick, Meret; Dyrba, Martin; Fritz, Hans-Christian J.; Altenstein, Slawek; Ballarini, Tommaso; Brosseron, Frederic; Buerger, Katharina; Cetindag, Arda Can; Dechent, Peter; Dobisch, Laura; Duezel, Emrah; Ertl-Wagner, Birgit; Fliessbach, Klaus; Freiesleben, Silka Dawn; Frommann, Ingo; Glanz, Wenzel; Haynes, John-Dylan; Heneka, Michael T.; Janowitz, Daniel; Kilimann, Ingo; Laske, Christoph; Metzger, Coraline D.; Munk, Matthias H.; Peters, Oliver; Priller, Josef; Roy, Nina; Scheffler, Klaus; Schneider, Anja; Spottke, Annika; Spruth, Eike Jakob; Tscheuschler, Maike; Vukovich, Ruth; Wiltfang, Jens; Jessen, Frank; Teipel, Stefan J.; Grothe, Michel J.

Venue: NeuroImage: Clinical

Type: Publication

Abstract: Dysfunction of the cholinergic basal forebrain (cBF) is associated with cognitive decline in Alzheimer's disease (AD). Multimodal MRI allows for the investigation of cBF changes in-vivo. In this study we assessed alterations in cBF functional connectivity (FC), mean diffusivity (MD), and volume across the spectrum of AD. We further assessed effects of amyloid pathology on these changes.Participants included healthy controls, and subjects with subjective cognitive decline (SCD), mild cognitive impairment (MCI), or AD dementia (ADD) from the mult... (read more)

DOI: 10.1016/j.nicl.2020.102495