BIP! Finder - The influence of genetic variants in SORL1 gene on the manifestation of Alzheimer's disease

2015 • The influence of genetic variants in SORL1 gene on the manifestation of Alzheimer's disease

Authors: Oliver Peters; Pieter Jelle Visser; Tim Becker; Yolande A.L. Pijnenburg; Eva Louwersheimer; Frank Jessen; Alfredo Ramirez; Jens Wiltfang; Wiesje M. van der Flier; Frederik Barkhof; Henne Holstege; Philip Scheltens; Johannes Kornhuber; Stefanie Heilmann; Carlos Cruchaga; John C. van Swieten; Charlotte E. Teunissen

Venue: Neurobiology of Aging

Type: Publication

Abstract: We studied the association of SORL1 single-nucleotide polymorphisms genotypes with measures of pathology in patients with probable Alzheimer's disease (AD) using an endophenotype approach. We included (1) 133 patients from the German Dementia Competence Network (71 ± 8 years; 50% females; Mini Mental State Examination [MMSE], 24 ± 3); (2) 83 patients from the Alzheimer's Disease Neuroimaging Initiative (75 ± 8 years; 45% females; MMSE, 24 ± 2); and (3) 452 patients from the Amsterdam Dementia Cohort 66 ± 8 years; 47% females; MMSE, 20 ± 5... (read more)

Topics: Internal medicine Genetics

DOI: 10.1016/j.neurobiolaging.2014.12.007

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External links: Crossref OpenAIRE

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