Authors: Eva Louwersheimer, Alfredo Ramirez, Carlos Cruchaga, Tim Becker, Johannes Kornhuber, Oliver Peters, Stefanie Heilmann, Jens Wiltfang, Frank Jessen, Pieter Jelle Visser, Philip Scheltens, Yolande A.L. Pijnenburg, Charlotte E. Teunissen, Frederik Barkhof, John C. van Swieten, Henne Holstege, Wiesje M. van der Flier

Venue: Neurobiology of Aging

Type: Publication

Abstract: We studied the association of SORL1 single-nucleotide polymorphisms genotypes with measures of pathology in patients with probable Alzheimer's disease (AD) using an endophenotype approach. We included (1) 133 patients from the German Dementia Competence Network (71 +/- 8 years; 50% females; Mini Mental State Examination [MMSE], 24 +/- 3); (2) 83 patients from the Alzheimer's Disease Neuroimaging Initiative (75 +/- 8 years; 45% females; MMSE, 24 +/- 2); and (3) 452 patients from the Amsterdam Dementia Cohort 66 +/- 8 years; 47% females; MMSE, 20... (read more)

DOI: 10.1016/j.neurobiolaging.2014.12.007