Authors: Pfuhler, S., Kirkland, D., Kasper, P., Hayashi, M., Vanparys, Carmichael, Dertinger, Eastmond, Elhajouji, A., Krul, C.A.M., Rothfuss, Schoening, G., Smith, Speit, Thomas, C., Benthem, J. van, Corvi, R.
Venue: Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Type: Publication
Abstract: In vivo genetic toxicology tests measure direct DNA damage or the formation of gene or chromosomal mutations, and are used to predict the mutagenic and carcinogenic potential of compounds for regulatory purposes and/or to follow-up positive results from in vitro testing. These tests are widely used and consume large numbers of animals, with a foreseeable marked increase as a result of the EU chemicals legislation (REACH), which may require follow-up of any positive outcome in the in vitro standard battery with appropriate in vivo tests, regardl...
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Topics: 
Toxicology
Pharmacology
Computational biology
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