Authors: David Kirkland, Stefan Pfuhler, David Tweats, Marilyn J. Aardema, Raffaella Corvi, Firouz Darroudi, Azeddine Elhajouji, Hansruedi Glatt, Paul W. Hastwell, M. Hayashi, Peter Kasper, Stephan Kirchner, Anthony M. Lynch, Daniel Marzin, Daniela Maurici, Jean-Roc Meunier, Lutz Müller, Gerhard J. Nohynek, James M. Parry, Elizabeth M. Parry, Véronique Thybaud, Ray Tice, Jan van Benthem, Philippe Vanparys, Paul D. White
Venue: Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Type: Publication
Abstract: Workshop participants agreed that genotoxicity tests in mammalian cells in vitro produce a remarkably high and unacceptable occurrence of irrelevant positive results (e.g. when compared with rodent carcinogenicity). As reported in several recent reviews, the rate of irrelevant positives (i.e. low specificity) for some studies using in vitro methods (when compared to this "gold standard") means that an increased number of test articles are subjected to additional in vivo genotoxicity testing, in many cases before, e.g. the efficacy (in the case ...
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Topics: 
Toxicology
Pharmacology
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