BIP! Finder - Memantine prevents cognitive impairment and reduces Bcl-2 and caspase 8 immunoreactivity in rats injected with amyloid β1

2012 • Memantine prevents cognitive impairment and reduces Bcl-2 and caspase 8 immunoreactivity in rats injected with amyloid β1–40

Authors: Valerie Wanzo; Jose Javier Miguel-Hidalgo; Ian A. Paul; Pradeep Banerjee

Venue: European Journal of Pharmacology

Type: Publication

Abstract: Amyloid-beta peptides (Aβ) can trigger apoptotic cascades in neurons. We found previously that memantine, an uncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors approved for the treatment of moderate to severe Alzheimer's disease, can prevent neurodegeneration induced by intracranial Aβ(1-40) injection. In this study, we tested the hypothesis that memantine prevents Aβ(1-40)-mediated cognitive impairment, neurodegeneration, and apoptosis of hippocampal neurons in rats. In addition, we hypothesized that Aβ(1-40) injection would... (read more)

Impact:

8.245662E-9 3.559717E-9 27 12

/ Attention: 0 32

Topics: Pharmacology Endocrinology Internal medicine

DOI: 10.1016/j.ejphar.2012.07.032

External links: Crossref OpenAIRE

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