BIP! Finder - Characteristics associated with serological COVID-19 vaccine response and durability in an older population with significant comorbidity: the Danish Nationwide ENFORCE Study

2022 • Characteristics associated with serological COVID-19 vaccine response and durability in an older population with significant comorbidity: the Danish Nationwide ENFORCE Study

Authors: Søgaard, Ole Schmeltz; Reekie, Joanne; Johansen, Isik Somuncu; Nielsen, Henrik; Benfield, Thomas; Wiese, Lothar; Stærke, Nina Breinholt; Iversen, Kasper; Fogh, Kamille; Bodilsen, Jacob; Iversen, Mette; Knudsen, Lene Surland; Klastrup, Vibeke; Larsen, Fredrikke Dam; Andersen, Sidsel Dahl; Hvidt, Astrid Korning; Andreasen, Signe Rode; Madsen, Lone Wulff; Lindvig, Susan Olaf; Øvrehus, Anne; Ostrowski, Sisse Rye; Abildgaard, Christiane; Matthews, Charlotte; Jensen, Tomas O.; Raben, Dorthe; Erikstrup, Christian; Fischer, Thea K.; Tolstrup, Martin; Østergaard, Lars; Lundgren, Jens

Venue: Clinical Microbiology and Infection

Type: Publication

Abstract: To identify individual characteristics associated with serological COVID-19 vaccine responsiveness and the durability of vaccine-induced antibodies.Adults without history of SARS-CoV-2 infection from the Danish population scheduled for SARS-CoV-2 vaccination were enrolled in this parallel group, phase 4 study. SARS-CoV-2 Spike IgG and Spike-ACE2-receptor-blocking antibodies were measured at days 0, 21, 90, and 180. Vaccine responsiveness was categorized according to Spike IgG and Spike-ACE2-receptor-blocking levels at day 90 after first vaccina... (read more)

Topics: Immunology Internal medicine Virology

DOI: 10.1016/j.cmi.2022.03.003

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