2020 •
FRETing over SARS-CoV-2: Conformational Dynamics of the Spike Glycoprotein
Authors: Serrão, Vitor Hugo B., Lee, Jeffrey E.
Venue: Cell Host & Microbe
Type: Publication
Abstract: In this issue of Cell Host & Microbe, Lu et al. utilize single-molecule FRET to reveal the conformation dynamics of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, showing transitions from a closed ground state to the open receptor-accessible conformation via an on-path intermediate. These insights into spike conformations will facilitate rational immunogen design.
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