Authors: Dittmann, Meike, Hoffmann, Hans-Heinrich, Scull, Margaret A., Gilmore, Rachel H., Bell, Kierstin L., Ciancanelli, Michael, Wilson, Sam J., Crotta, Stefania, Yu, Yingpu, Flatley, Brenna, Xiao, Jing W., Casanova, Jean-Laurent, Wack, Andreas, Bieniasz, Paul D., Rice, Charles M.
Venue: Cell
Type: Publication
Abstract: Summary Interferon-stimulated genes (ISGs) act in concert to provide a tight barrier against viruses. Recent studies have shed light on the contribution of individual ISG effectors to the antiviral state, but most have examined those acting on early, intracellular stages of the viral life cycle. Here, we applied an image-based screen to identify ISGs inhibiting late stages of influenza A virus (IAV) infection. We unraveled a directly antiviral function for the gene SERPINE1, encoding plasminogen activator inhibitor 1 (PAI-1). By targeting extra...
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Topics: 
Cell biology
Virology
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