2022 • Alcohol Increases Lung Angiotensin-Converting Enzyme 2 Expression and Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Subunit 1–Induced Acute Lung Injury in K18-hACE2 Transgenic Mice
Authors: Pavel A. Solopov; Ruben M.L. Colunga Biancatelli; John D. Catravas
Venue: The American Journal of Pathology
Type: Publication
Abstract: During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, alcohol consumption increased markedly. Nearly one in four adults reported drinking more alcohol to cope with stress. Chronic alcohol abuse is now recognized as a factor complicating the course of acute respiratory distress syndrome and increasing mortality. To investigate the mechanisms behind this interaction, a combined acute respiratory distress syndrome and chronic alcohol abuse mouse model was developed by intratracheally instilling the subunit 1 (S1) of SAR... (read more)
Topics:  Endocrinology Internal medicine Immunology
DOI: 10.1016/j.ajpath.2022.03.012
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External links: Crossref OpenAIRE
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