Abstract: Publisher Summary A reduced energy expenditure on non-shivering thermogenesis (NST) has been established as a primary cause of obesity in the genetically obese (ob/ob) and diabetic–obese (db/db) strains of mice. In newborn mammals and in hibernators, the brown adipose tissue (BAT) is the main site of NST, and Foster and Frydman have recently shown that this is also true for cold-exposed adult rodents. The presence of similar thermoregulatory abnormalities in ob/ob and db/db mice suggests that these two mutants may have a common metabolic basi...
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Topics:
Endocrinology
Internal medicine