Abstract: A new physiological pharmacokinetic model was used to explore the effect of exposure rate on the rate of formation of several crucial metabolites of benzene. Metabolite formation was compared following exposure to benzene over the course of an 8-hr workday and following a single exposure for 15 min. These exposures were based on the permissible exposure limit and short-term exposure limit of the benzene standard set by the Occupational Safety and Health Administration. The model was parametrized using in vitro and in vivo experimental data on b...
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Topics: 
Pharmacology
Toxicology