BIP! Finder - The derivation of quantitative correlations between skin sensitisation and physio-chemical parameters for alkylating agents, and their application to experimental data for sultones

1982 • The derivation of quantitative correlations between skin sensitisation and physio-chemical parameters for alkylating agents, and their application to experimental data for sultones

Authors: D.W. Roberts; D.L. Williams

Venue: Journal of Theoretical Biology

Type: Publication

Abstract: Abstract Quantitative relationships are derived, for skin sensitisation by alkylating agents, between sensitisation potential (as measured by the number of animals responding in a given test) and physico-chemical parameters. A composite parameter, the relative alkylation index ( RAI ), which is a function of chemical reactivity (measured in vitro ), lipophilicity (as expressed by a partition coefficient measured in vitro ) and dose administered, is used as a relative measure of the extent of in vivo alkylation produced by a given dose of a give... (read more)

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1.9077286E-8 2.6964114E-8 149 5

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Topics: Toxicology Pharmacology

DOI: 10.1016/0022-5193(82)90199-0

External links: Crossref OpenAIRE

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