Abstract: Abstract Quantitative relationships are derived, for skin sensitisation by alkylating agents, between sensitisation potential (as measured by the number of animals responding in a given test) and physico-chemical parameters. A composite parameter, the relative alkylation index ( RAI ), which is a function of chemical reactivity (measured in vitro ), lipophilicity (as expressed by a partition coefficient measured in vitro ) and dose administered, is used as a relative measure of the extent of in vivo alkylation produced by a given dose of a give...
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Topics: 
Toxicology
Pharmacology