BIP! Finder - Ion mobility spectrometry combined with multivariate statistical analysis: revealing the effects of a drug candidate for Alzheimer’s disease on Aβ1-40 peptide early assembly

2019 • Ion mobility spectrometry combined with multivariate statistical analysis: revealing the effects of a drug candidate for Alzheimer’s disease on Aβ1-40 peptide early assembly

Authors: Lazzaro, Serena; Ogrinc, Nina; Lamont, Lieke; Vecchio, Graziella; Pappalardo, Giuseppe; Heeren, Ron M A

Venue: Analytical and Bioanalytical Chemistry

Type: Publication

Abstract: Inhibition of the initial stages of amyloid-β peptide self-assembly is a key approach in drug development for Alzheimer's disease, in which soluble and highly neurotoxic low molecular weight oligomers are produced and aggregate in the brain over time. Here we report a high-throughput method based on ion mobility mass spectrometry and multivariate statistical analysis to rapidly select statistically significant early-stage species of amyloid-β1-40 whose formation is inhibited by a candidate theranostic agent. Using this method, we have confirm... (read more)

Topics: Chromatography

DOI: 10.1007/s00216-019-02030-7

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External links: Crossref OpenAIRE

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