Authors: Ruani N Fernando, Umesh Chaudhari, Sylvia Escher, Jan G. Hengstler, Jürgen Hescheler, Paul Jennings, Hector C. Keun, Jos C. S. Kleinjans, Raivo Kolde, Laxmikanth Kollipara, Annette Kopp-Schneider, Alice Limonciel, Harshal Nemade, Filomain Nguemo, Hedi Peterson, Pilar Prieto, Robim Marcelino Rodrigues, Agapios Sachinidis, Christoph Schäfer, Albert Sickmann, Dimitry Spitkovsky, Regina Stöber, Simone G. J. van Breda, Bob van de Water, Manon Vivier, René P. Zahedi, Mathieu Vinken, Vera Rogiers

Venue: Archives of Toxicology

Type: Publication

Abstract: SEURAT-1 is a joint research initiative between the European Commission and Cosmetics Europe aiming to develop in vitro- and in silico-based methods to replace the in vivo repeated dose systemic toxicity test used for the assessment of human safety. As one of the building blocks of SEURAT-1, the DETECTIVE project focused on a key element on which in vitro toxicity testing relies: the development of robust and reliable, sensitive and specific in vitro biomarkers and surrogate endpoints that can be used for safety assessments of chronically actin... (read more)

DOI: 10.1007/s00204-016-1719-6