Authors: Krug, A.K., Kolde, R., Gaspar, J.A., Rempel, E., Balmer, N.V., Meganathan, K., Vojnits, Baquié, M., Waldmann, T., Ensenat-Waser, Jagtap, S., Evans, R.M., Julien, Peterson, H., Zagoura, D., Kadereit, Gerhard, Sotiriadou, I., Heke, Natarajan, Henry, Winkler, J., Marchan, Stoppini, L., Bosgra, Westerhout, Verwei, Vilo, Kortenkamp, A., Hescheler, Hothorn, Bremer, Thriel, C. van, Krause, K.-H., Hengstler, J.G., Rahnenführer, Leist, Sachinidis
Venue: Archives of Toxicology
Type: Publication
Abstract: Developmental neurotoxicity (DNT) and many forms of reproductive toxicity (RT) often manifest themselves in functional deficits that are not necessarily based on cell death, but rather on minor changes relating to cell differentiation or communication. The fields of DNT/RT would greatly benefit from in vitro tests that allow the identification of toxicant-induced changes of the cellular proteostasis, or of its underlying transcriptome network. Therefore, the ‘human embryonic stem cell (hESC)-derived novel alternative test systems (ESNATS)’ ...
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Topics: 
Computational biology
Cell biology
Genetics
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