Abstract: AbstractThe importance of steric protection for the stability of phosphaalkenes RP=CI2 (6) was investigated by varying the size of group R. The phosphaalkene IsP=CI2 (6b) (Is = 2,4,6‐triisopropylphenyl) could be prepared in 15% isolated yield by reaction of IsPCl2 and HCI3 with two equivalents of lithium diisopropylamide, in analogy to the synthesis of the stable, sterically more protected, Mes*P = CI2 (6a) (Mes* = 2,4,6‐tri‐tert‐butylphenyl). If the steric protection on the phosphorus was decreased further (R = Es = 2,4,6‐triethylphe...
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Topics: 
Medicinal chemistry
Stereochemistry