BIP! Finder - Osteopontin stimulates invasion of NCI‐h295 cells but is not associated with survival in adrenocortical carcinoma

2009 • Osteopontin stimulates invasion of NCI‐h295 cells but is not associated with survival in adrenocortical carcinoma

Authors: Shereen Ezzat; Sarah Johanssen; Matthias Grüneberger; Patrick Adam; Wei Liu; Stefanie Hahner; Martin Fassnacht; Christoph M. Bamberger; Dirk Weismann; Bruno Allolio; Ana-Maria Bamberger; Joscha Niemann; Heinrich M. Schulte; Juliane Briese; Wolfgang Saeger; Sylvia L. Asa

Venue: The Journal of Pathology

Type: Publication

Abstract: Abstract Gene array studies indicated that osteopontin (OPN) mRNA is highly expressed in adrenocortical carcinomas (ACCs). OPN enhances invasiveness, proliferation, and metastasis formation, and is associated with poor survival in some malignant diseases. Integrin αvβ3 has been shown to mediate OPN effects on invasion. In this study, we demonstrated OPN and integrin αvβ3 expression in normal adrenal glands and benign adenomas, with staining seen exclusively in adrenocortical cells as well as even stronger staining in ACC. Western blot analy... (read more)

Impact:

3.0478837E-9 4.1564765E-9 13 8

/ Attention: 0 18

Topics: Cancer research Pathology

DOI: 10.1002/path.2528

External links: Crossref OpenAIRE

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