Abstract: AbstractInvasion of malignant tumor cells is required for the formation of metastatic colonies. Uncontrolled expression of matrix metalloproteinase (MMP)‐2 and MMP‐9 is a critical part of the invasive potential of tumor cells and is affected by the balance between the enzymes and the inhibitors secreted by the cell. Here we analyzed the expression and activity of the two gelatinases (MMP‐2 and MMP‐9) as well as the expression levels of the tissue inhibitor of metalloproteinase (TIMP2)‐, in different stages of carcinogenesis using mous...
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Topics: 
Cancer research
Molecular biology
Cell biology