Abstract: AbstractAbstract: Different cryo‐EM derived atomic models of in vivo tau filaments from patients with tauopathies consisted of R3 and R4 repeats of the microtubule‐binding domain. In comparison, only the R3 repeat forms the core of the heparin‐induced fibrils of the three repeat tau isoforms. For developing therapeutics, it is desirable to have an in vitro tau aggregation system producing fibrils corresponding to the disease morphology. Here we report the self‐aggregation of truncated tau segment R3R4 peptide without requiring heparin f...
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Topics: 
Biophysics
Biochemistry