Note: The reference list may be incomplete. This list contains all references that BIP software was able to retrieve.
Transcriptomics-based identification of developmental toxicants through their interference with cardiomyocyte differentiation of embryonic stem cells
Toxicology and Applied Pharmacology · 2010
Modelling and PBPK Simulation in Drug Discovery
The AAPS Journal · 2009
The Prediction of Drug Metabolism, Tissue Distribution, and Bioavailability of 50 Structurally Diverse Compounds in Rat Using Mechanism-Based Absorption, Distribution, and Metabolism Prediction Tools
Drug Metabolism and Disposition · 2007
Refining the threshold of toxicological concern (TTC) for risk prioritization of trace chemicals in food
Food and Chemical Toxicology · 2009
PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals
Toxicology · 2010
A loose-fit coculture of activated keratinocytes and dendritic cell-related cells for prediction of sensitizing potential
Allergy · 2007
T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays
Cellular and Molecular Life Sciences · 2010
An analysis of exposure rate effects for benzene using a physiologically based pharmacokinetic model
Regulatory Toxicology and Pharmacology · 1992
The contribution of in vitro toxicity data in hazard and risk assessment: Current limitations and future perspectives
Toxicology Letters · 2008
A review of the scientific basis for uncertainty factors for use in quantitative risk assessment for the induction of allergic contact dermatitis
Contact Dermatitis · 2002
A framework for using structural, reactivity, metabolic and physicochemical similarity to evaluate the suitability of analogs for SAR-based toxicological assessments
Regulatory Toxicology and Pharmacology · 2010
Gene expression profiling in primary mouse hepatocytes discriminates true from false-positive genotoxic compounds
Mutagenesis · 2010
The National Toxicology Program Evaluation of Genetically Altered Mice as Predictive Models for Identifying Carcinogens
Toxicologic Pathology · 1998
The Current Scientific and Legal Status of Alternative Methods to the LD50 Test for Botulinum Neurotoxin Potency Testing
Alternatives to Laboratory Animals · 2010
Classification of sensitizing and irritative potential in a combined in-vitro assay
Toxicology and Applied Pharmacology · 2010
Adenovirus-mediated hepatocyte nuclear factor-4α overexpression maintains liver phenotype in cultured rat hepatocytes
Biochemical and Biophysical Research Communications · 2005
Understanding mechanisms of toxicity: Insights from drug discovery research
Toxicology and Applied Pharmacology · 2008
Differential susceptibilities of Holtzman and Sprague–Dawley rats to fetal death and placental dysfunction induced by 2,3,7,8-teterachlorodibenzo-p-dioxin (TCDD) despite the identical primary structure of the aryl hydrocarbon receptor
Toxicology and Applied Pharmacology · 2006
Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities—Report from an ECVAM workshop
Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 2009
The immediate early genes, c-fos, c-jun and AP-1, are early markers of platinum analogue toxicity in human proximal tubular cell primary cultures
Toxicology in Vitro · 2009
Computer Prediction of Possible Toxic Action from Chemical Structure; The DEREK System
Human & Experimental Toxicology · 1991
An evaluation of selected global (Q)SARs/expert systems for the prediction of skin sensitisation potential
SAR and QSAR in Environmental Research · 2007
Analysis of published data for top concentration considerations in mammalian cell genotoxicity testing
Mutagenesis · 2010
Epigenomics and breast cancer
Pharmacogenomics · 2008
Mechanisms of Nongenotoxic Carcinogenesis and Assessment of the Human Hazard
Regulatory Toxicology and Pharmacology · 2000
Estrogenic in vitro assay on mouse embryonic Leydig cells
The International Journal of Developmental Biology · 2010
What do we Mean by Dose
Inhalation Toxicology · 1995
Comparison of the skin sensitizing potential of unsaturated compounds as assessed by the murine local lymph node assay (LLNA) and the guinea pig maximization test (GPMT)
Food and Chemical Toxicology · 2008
Metabolism: A Bottleneck inIn VitroToxicological Test Development
Alternatives to Laboratory Animals · 2006
True prediction of lowest observed adverse effect levels
Molecular Diversity · 2006
Critical analysis of the SCCNFP/SCCP safety assessment of cosmetic ingredients (2000–2006)
Food and Chemical Toxicology · 2009
Detection of potential (anti)progestagenic endocrine disruptors using a recombinant human progesterone receptor binding and transactivation assay
Molecular and Cellular Endocrinology · 2008
Testing Potential Developmental Toxicants with a Cytotoxicity Assay Based on Human Embryonic Stem Cells
Alternatives to Laboratory Animals · 2008
Reactivity Profiling: Covalent Modification of Single Nucleophile Peptides for Skin Sensitization Risk Assessment
Toxicological Sciences · 2009
The Threshold of Toxicological Concern (TTC) in risk assessment
Toxicology Letters · 2008
Methods for reliability and uncertainty assessment and for applicability evaluations of classification- and regression-based QSARs.
Environmental Health Perspectives · 2003
An Exploratory Study of Two Caco-2 Cell Models for Oral Absorption: A Report on Their Within-laboratory and Between-laboratory Variability, and Their Predictive Capacity
Alternatives to Laboratory Animals · 2010
Integrating (Q)SAR models, expert systems and read-across approaches for the prediction of developmental toxicity
Reproductive Toxicology · 2010
(Q)SARs for Predicting Effects Relating to Reproductive Toxicity
QSAR & Combinatorial Science · 2008
A comparison of statistical approaches to the derivation of EC3 values from local lymph node assay dose responses
Journal of Applied Toxicology · 1999
Placental Passage of Benzoic acid, Caffeine, and Glyphosate in an Ex Vivo Human Perfusion System
Journal of Toxicology and Environmental Health, Part A · 2008
Non-animal sensitization testing: State-of-the-art
Critical Reviews in Toxicology · 2010
Determinants of skin sensitisation potential
Journal of Applied Toxicology · 2008
Updating the Skin Sensitizationin VitroData Assessment Paradigm in 2009 - a chemistry and QSAR perspective
Journal of Applied Toxicology · 2010
Effects and uptake of gold nanoparticles deposited at the air–liquid interface of a human epithelial airway model
Toxicology and Applied Pharmacology · 2010
Use of the fertilized hen's egg in the evaluation of embryotoxicity of dental alloys
Journal of Biomedical Materials Research Part B: Applied Biomaterials · 2004
REPDOSE: A database on repeated dose toxicity studies of commercial chemicals—A multifunctional tool
Regulatory Toxicology and Pharmacology · 2006
How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop
Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 2007
Xenobiotic metabolism gene expression in the EpiDerm™ in vitro 3D human epidermis model compared to human skin
Toxicology in Vitro · 2010
REVIEWCytokines and chemokines in the initiation and regulation of epidermal Langerhans cell mobilization
British Journal of Dermatology · 2000
Statistical Issues in Toxicokinetic Modeling: A Bayesian Perspective
Environmental Health Perspectives · 2000
In VitroEvaluation of Metabolic Drug-Drug Interactions: Scientific Concepts and Practical Considerations
Pharmaceutical Sciences Encyclopedia · 2010
A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates
Drug Metabolism and Pharmacokinetics · 2009
In Vitro Zonation and Toxicity in a Hepatocyte Bioreactor
Toxicological Sciences · 2005
ReProComet: A New In Vitro Method to Assess DNA Damage in Mammalian Sperm
Toxicological Sciences · 2007
Contact allergy, irritancy and ‘danger’
Contact Dermatitis · 2000
In vitro assessment of AhR-mediated activities of TCDD in mixture with humic substances
Chemosphere · 2009
Identification of toxicological biomarkers of di(2-ethylhexyl) phthalate in proteins secreted by HepG2 cells using proteomic analysis
Gene markers in dendritic cells unravel pieces of the skin sensitization puzzle
Toxicology Letters · 2010
Use of reporter cell lines for detection of endocrine-disrupter activity
Analytical and Bioanalytical Chemistry · 2004
3.9. Toxicokinetics and Metabolism
Alternatives to Laboratory Animals · 2005
Dendritic Cells
Cell · 2001
Routine teratogenicity test that uses chick embryos in vitro
Teratogenesis, Carcinogenesis, and Mutagenesis · 1987
Non-Animal Approaches for Consumer Safety Risk Assessments: Unilever's Scientific Research Programme
Alternatives to Laboratory Animals · 2009
Preclinical assessment of cardiac toxicity
Drug Discovery Today · 2008
Monolayer cultivation of osteoprogenitors shortens duration of the embryonic stem cell test while reliably predicting developmental osteotoxicity
Toxicology · 2010
Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens
Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 2005
Modified in vitro conditions for cord blood–derived long-term culture-initiating cells
Experimental Hematology · 2001
The local lymph node assay and skin sensitization: a cut-down screen to reduce animal requirements?
Contact Dermatitis · 2006
The assessment of estrogenic or anti-estrogenic activity of chemicals by the human stably transfected estrogen sensitive MELN cell line: Results of test performance and transferability
Reproductive Toxicology · 2010
Alternatives to the carcinogenicity bioassay:in silicomethods, and thein vitroandin vivomutagenicity assays
Expert Opinion on Drug Metabolism & Toxicology · 2010
Concordance of the Toxicity of Pharmaceuticals in Humans and in Animals
Regulatory Toxicology and Pharmacology · 2000
Toxicological comments to the discussion about REACH
Archives of Toxicology · 2006
Developmental expression of drug metabolizing enzymes and transporter proteins in human placenta and fetal tissues
Expert Opinion on Drug Metabolism & Toxicology · 2009
The Role Of Transgenic Mouse Models In Carcinogen Identification.
Environmental Health Perspectives · 2002
Toxicogenomics Applied to In Vitro Carcinogenicity Testing with Balb/c 3T3 Cells Revealed a Gene Signature Predictive of Chemical Carcinogens
Toxicological Sciences · 2010
Kinetic Glutathione Chemoassay To Quantify Thiol Reactivity of Organic Electrophiles—Application to α,β-Unsaturated Ketones, Acrylates, and Propiolates
Chemical Research in Toxicology · 2009
Identification of the Structural Requirements for Mutagenicity by Incorporating Molecular Flexibility and Metabolic Activation of Chemicals I: TA100 Model
Chemical Research in Toxicology · 2004
An improved protocol for primary culture of cardiomyocyte from neonatal mice
In Vitro Cellular & Developmental Biology - Animal · 2008
Evaluation of changes of cell-surface thiols as a new biomarker for in vitro sensitization test
Toxicology in Vitro · 2009
Innervated human corneal equivalents as in vitro models for nerve‐target cell interactions
The FASEB Journal · 2003
Assuring safety without animal testing: Unilever’s ongoing research programme to deliver novel ways to assure consumer safety
ALTEX · 2010
In Vitro Thyroid Hormone–disrupting Activity In Effluents And Surface Waters In Thailand
Environmental Toxicology and Chemistry · 2009
A New View of Carcinogenesis and an Alternative Approach to Cancer Therapy
Molecular Medicine · 2009
A Gene Expression Biomarker Provides Early Prediction and Mechanistic Assessment of Hepatic Tumor Induction by Nongenotoxic Chemicals
Toxicological Sciences · 2007
The need for a new toxicity testing and risk analysis paradigm to implement REACH or any other large scale testing initiative
Archives of Toxicology · 2007
Prediction of non-genotoxic carcinogenesis in rats using changes in gene expression following acute dosing
Chemico-Biological Interactions · 2008
Development of a New Screening Assay to Identify Proteratogenic Substances using Zebrafish Danio rerio Embryo Combined with an Exogenous Mammalian Metabolic Activation System (mDarT)
Toxicological Sciences · 2008
Development of a zebrafish embryo teratogenicity assay and quantitative prediction model
Birth Defects Research Part B: Developmental and Reproductive Toxicology · 2010
Exposure based waiving: The application of the toxicological threshold of concern (TTC) to inhalation exposure for aerosol ingredients in consumer products
Food and Chemical Toxicology · 2009
Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
Regulatory Toxicology and Pharmacology · 2004
Integrated Computational Methods for Prediction of the Lowest Observable Adverse Effect Level of Food-Borne Molecules
QSAR & Combinatorial Science · 2007
ACS Symposium Series · 1992
Expectations for Transgenic Rodent Cancer Bioassay Models
Toxicologic Pathology · 2001
Phase III interlaboratory study of FETAX part 3. FETAX validation using 12 compounds with and without an exogenous metabolic activation system
Journal of Applied Toxicology · 1999
Incorporating Physiological and Biochemical Mechanisms into Pharmacokinetic-Pharmacodynamic Models: A Conceptual Framework
Basic & Clinical Pharmacology & Toxicology · 2009
An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture
Biotechnology and Bioengineering · 2007
Metabolism and Toxicity of Drugs. Two Decades of Progress in Industrial Drug Metabolism
Chemical Research in Toxicology · 2007
Applications of microarrays with toxicologically relevant genes (tox genes) for the evaluation of chemical toxicants in Sprague Dawley rats in vivo and human hepatocytes in vitro
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis · 2004
The hen's egg test for micronucleus induction (HET-MN): Novel analyses with a series of well-characterized substances support the further evaluation of the test system
Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 2008
Identification of a gene expression profile that discriminates indirect-acting genotoxins from direct-acting genotoxins
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis · 2004
Human primary renal cells as a model for toxicity assessment of chemo-therapeutic drugs
Toxicology in Vitro · 2006
Development of an in vitro exposure model for investigating the biological effects of therapeutic aerosols on human cells from the respiratory tract
Experimental and Toxicologic Pathology · 2011
Safety assessment of personal care products/cosmetics and their ingredients
Toxicology and Applied Pharmacology · 2010
The local lymph node assay and the assessment of relative potency: status of validation
Contact Dermatitis · 2007
The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements
Nature Biotechnology · 2006
Identification and dissection of the Nrf2 mediated oxidative stress pathway in human renal proximal tubule toxicity
Toxicology in Vitro · 2011
Review of QSAR Models and Software Tools for Predicting of Genotoxicity and Carcinogenicity
N/A · 2010
Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?
Nature Reviews Cancer · 2006
An alternative approach for the safety evaluation of new and existing chemicals, an exercise in integrated testing
Regulatory Toxicology and Pharmacology · 2005
Report and Recommendations of the Workshop of the European Centre for the Validation of Alternative Methods for Drug-Induced Cardiotoxicity
Cardiovascular Toxicology · 2009
In Vitro Testing for Direct Immunotoxicity: State of the Art
Methods in Molecular Biology · 2009
A Modular Approach to the ECVAM Principles on Test Validity
Alternatives to Laboratory Animals · 2004
QSAR models for reproductive toxicity and endocrine disruption in regulatory use – a preliminary investigation
SAR and QSAR in Environmental Research · 2008
An in vitro assay for teratogens with cultures of rat embryo midbrain and limb bud cells
Toxicology and Applied Pharmacology · 1984
The methoxychlor metabolite, 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane, inhibits steroidogenesis in rat ovarian granulosa cells in vitro
Reproductive Toxicology · 2006
Establishment of an Embryotoxicity Assay with Green Fluorescence Protein-expressing Embryonic Cell-derived Cardiomyocytes
Alternatives to Laboratory Animals · 1999
Sixth Plot of the Carcinogenic Potency Database: Results of Animal Bioassays Published in the General Literature 1989 to 1990 and by the National Toxicology Program 1990 to 1993
Environmental Health Perspectives · 1995
Quantitative Interpretation of Human Biomonitoring Data
Toxicology and Applied Pharmacology · 2008
Application of Key Events Analysis to Chemical Carcinogens and Noncarcinogens
Critical Reviews in Food Science and Nutrition · 2009
Hazard assessment of methylmercury toxicity to neuronal induction in embryogenesis using human embryonic stem cells
Toxicology · 2009
Placental transport and in vitro effects of Bisphenol A
Reproductive Toxicology · 2010
Evaluation of inhalation TTC values with the database RepDose
Regulatory Toxicology and Pharmacology · 2010
Feasibility study to support a threshold of sensitization concern concept in risk assessment based on human data
Archives of Toxicology · 2009
Determining Epidermal Disposition Kinetics for Use in an Integrated Nonanimal Approach to Skin Sensitization Risk Assessment
Toxicological Sciences · 2010
Steroid receptor profiling of vinclozolin and its primary metabolites
Toxicology and Applied Pharmacology · 2006
Assessment of the U937 cell line for the detection of contact allergens
Toxicology and Applied Pharmacology · 2007
Trichostatin A, a critical factor in maintaining the functional differentiation of primary cultured rat hepatocytes
Toxicology and Applied Pharmacology · 2007
Transcriptional Activation of CYP2C9, CYP1A1, and CYP1A2 by Hepatocyte Nuclear Factor 4α Requires Coactivators Peroxisomal Proliferator Activated Receptor-γ Coactivator 1α and Steroid Receptor Coactivator 1
Molecular Pharmacology · 2006
Novel Advanced In Vitro Methods for Long-term Toxicity Testing
Alternatives to Laboratory Animals · 2001
Use of a Low-Density Microarray for Studying Gene Expression Patterns Induced by Hepatotoxicants on Primary Cultures of Rat Hepatocytes
Toxicological Sciences · 2003
Further analysis of Ames-negative rodent carcinogens that are only genotoxic in mammalian cells in vitro at concentrations exceeding 1 mM, including retesting of compounds of concern
Mutagenesis · 2010
Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion
Toxicology in Vitro · 2009
Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet
Food and Chemical Toxicology · 2004
International prevalidation studies of the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay: Transferability and reproducibility
Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 2010
Toxicology databases and the concept of thresholds of toxicological concern as used by the JECFA for the safety evaluation of flavouring agents
Toxicology Letters · 2004
From known knowns to known unknowns: predicting in vivo drug metabolites
Bioanalysis · 2009
Modification and evaluation of the chicken embryotoxicity screening test (CHEST) as in vitro test system for embryotoxicity
Toxicology Letters · 2009
Comparison of metabolic stability and metabolite identification of 55 ECVAM/ICCVAM validation compounds between human and rat liver homogenates and microsomes - a preliminary analysis
ALTEX · 2009
Application of a Systems Biology Approach to Skin Allergy Risk Assessment
Alternatives to Laboratory Animals · 2008
Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism‐Based Prediction of Volume of Distribution
Journal of Pharmaceutical Sciences · 2002
Predictive toxicogenomics approaches reveal underlying molecular mechanisms of nongenotoxic carcinogenicity
Molecular Carcinogenesis · 2006
A newin vitromethod for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells
Cutaneous and Ocular Toxicology · 2010
Immune function testing for the identification and characterisation of immunotoxicity in rodents
Human & Experimental Toxicology · 1995
Characterization of primary rat proximal tubular cells by gene expression analysis
Toxicology in Vitro · 2007
Preservatives and Skin Sensitization Quantitative Risk Assessment
Dermatitis · 2008
Methyldibromoglutaronitrile: skin sensitization and quantitative risk assessment
Cutaneous and Ocular Toxicology · 2009
The derivation of quantitative correlations between skin sensitisation and physio-chemical parameters for alkylating agents, and their application to experimental data for sultones
Journal of Theoretical Biology · 1982
In vivo drug discovery in the zebrafish
Nature Reviews Drug Discovery · 2005
Endocrine Disruption Modeling
N/A · 2009
Cells on chips
Nature · 2006
New public QSAR model for carcinogenicity
Chemistry Central Journal · 2010
Effector and regulatory mechanisms in allergic contact dermatitis
Allergy · 2009
Discriminating Different Classes of Toxicants by Transcript Profiling
Environmental Health Perspectives · 2004
Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues
Toxicology and Applied Pharmacology · 1989
Update on national toxicology program (NTP) assays with genetically altered or "transgenic" mice.
Environmental Health Perspectives · 1998
Investigation of Peptide Reactivity of Pro-hapten Skin Sensitizers Using a Peroxidase-Peroxide Oxidation System
Toxicological Sciences · 2009
Differentiation of neonatal rat epithelial cells from biliary origin into immature hepatic cells by sequential exposure to hepatogenic cytokines and growth factors reflecting liver development
Toxicology in Vitro · 2007
Modelling of the blood–brain barrier in drug discovery and development
Nature Reviews Drug Discovery · 2007
Toxicity Testing in the 21st Century: Using the New Toxicity Testing Paradigm to Create a Taxonomy of Adverse Effects
Toxicological Sciences · 2009
Computer prediction of possible toxic action from chemical structure: an update on the DEREK system
Toxicology · 1996
A sandwich-cultured rat hepatocyte system with increased metabolic competence evaluated by gene expression profiling
Toxicology in Vitro · 2007
Early gene expression changes during embryonic stem cell differentiation into cardiomyocytes and their modulation by monobutyl phthalate
Reproductive Toxicology · 2009
How to assess the mutagenic potential of cosmetic products without animal tests?
Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 2009
Use of IL-18 production in a human keratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory allergens
Toxicology in Vitro · 2009
Recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests: A follow-up to an ECVAM workshop
Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 2008
Additive SMILES-Based Carcinogenicity Models: Probabilistic Principles in the Search for Robust Predictions
International Journal of Molecular Sciences · 2009
A Category Approach for Reproductive Effects of Phthalates
Critical Reviews in Toxicology · 2006
Characterization and Interlaboratory Comparison of a Gene Expression Signature for Differentiating Genotoxic Mechanisms
Toxicological Sciences · 2009
Inhibition and induction of human cytochrome P450 enzymes: current status
Archives of Toxicology · 2008
An Expert System Approach to the Assessment of Hepatotoxic Potential
Chemistry & Biodiversity · 2009
Updating the skin sensitizationin vitrodata assessment paradigm in 2009
Journal of Applied Toxicology · 2009
Electrophilic Chemistry Related to Skin Sensitization. Reaction Mechanistic Applicability Domain Classification for a Published Data Set of 106 Chemicals Tested in the Mouse Local Lymph Node Assay
Chemical Research in Toxicology · 2006
Diagnosis of drug-induced renal tubular toxicity using global gene expression profiles
Journal of Translational Medicine · 2007
Application of the CFU-GM Assay to Predict Acute Drug-Induced Neutropenia: An International Blind Trial to Validate a Prediction Model for the Maximum Tolerated Dose (MTD) of Myelosuppressive Xenobiotics
Toxicological Sciences · 2003
Incorporation of 3T3-L1 Cells To Mimic Bioaccumulation in a Microscale Cell Culture Analog Device for Toxicity Studies
Biotechnology Progress · 2008
A Preliminary Operational Classification System for Nonmutagenic Modes of Action for Carcinogenesis
Critical Reviews in Toxicology · 2009
Development of a novel method for predicting human volume of distribution at steady-state of basic drugs and comparative assessment with existing methods
Journal of Pharmaceutical Sciences · 2009
Estimation of Systemic Toxicity of Acrylamide by Integration of in Vitro Toxicity Data with Kinetic Simulations
Toxicology and Applied Pharmacology · 1999
Predicting in vivo gene expression in macrophages after exposure to benzo(a)pyrene based on in vitro assays and toxicokinetic/toxicodynamic models
Toxicology Letters · 2011
Validation of a Rapid Equilibrium Dialysis Approach for the Measurement of Plasma Protein Binding
Journal of Pharmaceutical Sciences · 2008
Investigation Of A Hepatotoxicity Screening System In Primary Cell Cultures-"what Biomarkers Would Need To Be Addressed To Estimate Toxicity In Conventional And New Approaches?"-
The Journal of Toxicological Sciences · 2005
An Integrated Approach to the Prediction of Systemic Toxicity using Computer-based Biokinetic Models and Biological In vitro Test Methods: Overview of a Prevalidation Study Based on the ECITTS Project
Toxicology in Vitro · 1999
In silico approaches to predicting cancer potency for risk assessment of genotoxic impurities in drug substances
Regulatory Toxicology and Pharmacology · 2010
Identification of Early Proteomic Markers for Hepatic Steatosis
Chemical Research in Toxicology · 2006
The murine local lymph node assay: A commentary on collaborative studies and new directions
Food and Chemical Toxicology · 1992
Toward More Useful In Vitro Toxicity Data with Measured Free Concentrations
Environmental Science & Technology · 2004
Transferability and inter-laboratory variability assessment of the in vitro bovine oocyte maturation (IVM) test within ReProTect
Reproductive Toxicology · 2010
Cord Blood Stem and Progenitor Cells
Adult Stem Cells · 2006
A Toxicogenomic Approach to Drug-Induced Phospholipidosis: Analysis of Its Induction Mechanism and Establishment of a Novel in Vitro Screening System
Toxicological Sciences · 2004
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 3 (FGE.03); Acetals of branched- and straight-chain aliphatic saturated primary alcohols and br
EFSA Journal · 2004
Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models.
Environmental Health Perspectives · 1995
Discovery of estrogen receptor modulators: a review of virtual screening and SAR efforts
Expert Opinion on Drug Discovery · 2009
Rapid and Simple Kinetics Screening Assay for Electrophilic Dermal Sensitizers Using Nitrobenzenethiol
Chemical Research in Toxicology · 2010
Assessment of the Oral Rat Chronic Lowest Observed Adverse Effect Level Model in TOPKAT, a QSAR Software Package for Toxicity Prediction
Journal of Chemical Information and Computer Sciences · 2004
Mechanisms and Consequences of Drug-Drug Interactions
Preclinical Development Handbook · 2007
Response : Carcinogens and Human Health: Part 3
Science · 1991
LC-MS–Based Characterization of the Peptide Reactivity of Chemicals to Improve the In Vitro Prediction of the Skin Sensitization Potential
Toxicological Sciences · 2008
o,p′-DDT and its metabolites inhibit progesterone-dependent responses in yeast and human cells
Molecular and Cellular Endocrinology · 1997
The relationship between CD86/CD54 expression and THP-1 cell viability in an in vitro skin sensitization test – human cell line activation test (h-CLAT)
Cell Biology and Toxicology · 2008
Modification of cell-surface thiols elicits activation of human monocytic cell line THP-1: Possible involvement in effect of haptens 2,4-dinitrochlorobenzene and nickel sulfate
The Journal of Toxicological Sciences · 2009
Skin sensitization in chemical risk assessment: Report of a WHO/IPCS international workshop focusing on dose–response assessment
Regulatory Toxicology and Pharmacology · 2008
Prediction of chemical toxicity with local support vector regression and activity-specific kernels
SAR and QSAR in Environmental Research · 2008
Brain drug targeting: a computational approach for overcoming blood–brain barrier
Drug Discovery Today · 2009
ECVAM prevalidation of three cell transformation assays
ALTEX · 2011
Thresholds of Toxicological Concern Based on Structure-Activity Relationships
Drug Metabolism Reviews · 1996
Trends in microdosing and other exploratory human pharmacokinetic studies for early drug development
Bioanalysis · 2010
Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies
Drug Metabolism Reviews · 2007
Toxicogenomics: Overview and potential applications for the study of non-covalent DNA interacting chemicals
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis · 2007
An engineered 3D blood-testis barrier model for the assessment of reproductive toxicity potential
Biomaterials · 2010
Structure–activity relationships for reactivity of carbonyl-containing compounds with glutathione
SAR and QSAR in Environmental Research · 2005
Understanding fragrance allergy using an exposure-based risk assessment approach
Contact Dermatitis · 2001
The Acquisition and Application of Absorption, Distribution, Metabolism, and Excretion (ADME) Data in Agricultural Chemical Safety Assessments
Critical Reviews in Toxicology · 2006
Development of an in vitro skin sensitization test using human cell lines: The human Cell Line Activation Test (h-CLAT)
Toxicology in Vitro · 2006
In vitro effects of dexamethasone on mouse ovarian function and pre-implantation embryo development
Reproductive Toxicology · 2007
Evaluation of the protein binding ratio of drugs by a micro-scale ultracentrifugation method
Journal of Pharmaceutical Sciences · 2004
A Tiered Approach to Life Stages Testing for Agricultural Chemical Safety Assessment
Critical Reviews in Toxicology · 2006
Rat toxicogenomic study reveals analytical consistency across microarray platforms
Nature Biotechnology · 2006
In vitro techniques for the assessment of neurotoxicity.
Environmental Health Perspectives · 1998
Automated analysis of contractility in the embryonic stem cell test, a novel approach to assess embryotoxicity
Toxicology in Vitro · 2008
Optimal design for a study of butadiene toxicokinetics in humans
Toxicological Sciences · 1999
Predictivity of QSAR
Journal of Chemical Information and Modeling · 2008
In vitro–in vivo extrapolation: estimation of human serum concentrations of chemicals equivalent to cytotoxic concentrations in vitro
Toxicology · 2003
REACH, non-testing approaches and the urgent need for a change in mind set
Regulatory Toxicology and Pharmacology · 2009