Note: The citation list may be incomplete. This list contains all citations that BIP software was able to retrieve.
Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates
The EMBO Journal · 2022
       
Deciphering the Structure and Formation of Amyloids in Neurodegenerative Diseases With Chemical Biology Tools
Frontiers in Chemistry · 2022
       
The contribution of electrostatics to hydrogen exchange in the unfolded protein state
Biophysical Journal · 2021
       
Tau and Membranes: Interactions That Promote Folding and Condensation
Frontiers in Cell and Developmental Biology · 2021
       
Molecular Determinants of Liquid Demixing and Amyloidogenesis in Human CPEB3
Biorxiv · 2020
       
Regulation of liquid–liquid phase separation with focus on post-translational modifications
Chemical Communications · 2021
       
Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation
Journal of Biological Chemistry · 2019
       
Phase Separation and Neurodegenerative Diseases: A Disturbance in the Force
Developmental Cell · 2020
       
The Role of Post-Translational Modifications on the Structure and Function of Tau Protein
Journal of Molecular Neuroscience · 2022
       
The Structure Biology of Tau and Clue for Aggregation Inhibitor Design
The Protein Journal · 2021
       
How do protein aggregates escape quality control in neurodegeneration?
Trends in Neurosciences · 2022
       
Molecular mechanism for the synchronized electrostatic coacervation and co-aggregation of alpha-synuclein and tau
Nature Communications · 2022
       
Tau-mediated dysregulation of RNA: Evidence for a common molecular mechanism of toxicity in frontotemporal dementia and other tauopathies
Neurobiology of Disease · 2020
       
Relevance of Electrostatic Charges in Compactness, Aggregation, and Phase Separation of Intrinsically Disordered Proteins
International Journal of Molecular Sciences · 2020
       
New Insights Into Drug Discovery Targeting Tau Protein
Frontiers in Molecular Neuroscience · 2020
       
Liquid-liquid phase separation induces pathogenic tau conformations in vitro
Nature Communications · 2020
       
Zinc promotes liquid–liquid phase separation of tau protein
Journal of Biological Chemistry · 2020
       
Curcumin Interacts with α-Synuclein Condensates To Inhibit Amyloid Aggregation under Phase Separation
ACS Omega · 2022
       
How Glutamate Promotes Liquid-liquid Phase Separation and DNA Binding Cooperativity of E. coli SSB Protein
Journal of Molecular Biology · 2022
       
Atomic Level Investigations of Early Aggregation of Tau43 in Water I. Conformational Propensity of Monomeric Tau43
Bulletin of the Korean Chemical Society · 2021
       
Protein Aggregation Landscape in Neurodegenerative Diseases: Clinical Relevance and Future Applications
International Journal of Molecular Sciences · 2021
       
Conformational Expansion of Tau in Condensates Promotes Irreversible Aggregation
Journal of the American Chemical Society · 2021
       
Electrostatic interactions in molecular recognition of intrinsically disordered proteins
Journal of Biomolecular Structure and Dynamics · 2019
       
Protein droplets in systems of disordered homopeptides and the amyloid glass phase
Physical Chemistry Chemical Physics · 2020
       
SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA
PLOS Biology · 2021
       
Calcium promotes α-synuclein liquid-liquid phase separation to accelerate amyloid aggregation
Biochemical and Biophysical Research Communications · 2022
       
Multiphase Complex Coacervate Droplets
Journal of the American Chemical Society · 2020
       
Solution NMR insights into dynamic supramolecular assemblies of disordered amyloidogenic proteins
Archives of Biochemistry and Biophysics · 2020
       
In vitro characterization and molecular dynamics simulation reveal mechanism of 14-3-3ζ regulated phase separation of the tau protein
International Journal of Biological Macromolecules · 2022
       
Phase Separation and Cytotoxicity of Tau are Modulated by Protein Disulfide Isomerase and S-nitrosylation of this Molecular Chaperone
Journal of Molecular Biology · 2020
       
Small molecules as potent biphasic modulators of protein liquid-liquid phase separation
Nature Communications · 2020
       
Myricetin slows liquid–liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity
Journal of Biological Chemistry · 2021
       
Looking Beyond the Core: The Role of Flanking Regions in the Aggregation of Amyloidogenic Peptides and Proteins
Frontiers in Neuroscience · 2020
       
Liquid–liquid phase separation of Tau by self and complex coacervation
Protein Science · 2021
       
Temperature-dependent reentrant phase transition of RNA–polycation mixtures
Soft Matter · 2022
       
Ubiquitination of Alzheimer's-related tau protein affects liquid-liquid phase separation in a site- and cofactor-dependent manner
International Journal of Biological Macromolecules · 2022
       
Granulins modulate liquid-liquid phase separation and aggregation of TDP-43 C-terminal domain
Biorxiv · 2019
       
Biomolecular Tau condensation is linked to Tau accumulation at the nuclear envelope
N/A · 2022
       
Valence-induced jumps in coacervate properties
Science Advances · 2022
       
Mechanisms and regulation underlying membraneless organelle plasticity control
Journal of Molecular Cell Biology · 2021
       
Phospho-Tau and Chromatin Landscapes in Early and Late Alzheimer’s Disease
International Journal of Molecular Sciences · 2021
       
Pathologic tau conformer ensembles induce dynamic, liquid-liquid phase separation events at the nuclear envelope
BMC Biology · 2021
       
An Interpretable Machine-Learning Algorithm to Predict Disordered Protein Phase Separation Based on Biophysical Interactions
Biomolecules · 2022
       
How Glutamate Promotes Liquid-liquid Phase Separation and DNA Binding Cooperativity of E. coli SSB Protein
N/A · 2022
       
Uncharged Components of Single-Stranded DNA Modulate Liquid–Liquid Phase Separation With Cationic Linker Histone H1
Frontiers in Cell and Developmental Biology · 2021
       
14-3-3 Proteins are Potential Regulators of Liquid–Liquid Phase Separation
Cell Biochemistry and Biophysics · 2022
       
Intrinsically disordered protein regions at membrane contact sites
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · 2021
       
Tau N-Terminal Inserts Regulate Tau Liquid-Liquid Phase Separation and Condensates Maturation in a Neuronal Cell Model
International Journal of Molecular Sciences · 2021
       
The synergic effect of water and biomolecules in intracellular phase separation
Nature Reviews Chemistry · 2019
       
Capturing protein droplets: label-free visualization and detection of protein liquid–liquid phase separation with an aggregation-induced emission fluorogen
Chemical Communications · 2021
       
Direct Observation of the Self‐Aggregation of R3R4 Bi‐repeat of Tau Protein
ChemBioChem · 2021
       
Man does not live by intrinsically unstructured proteins alone: The role of structured regions in aggregation
BioEssays · 2021
       
Liquid–liquid phase separation in human health and diseases
Signal Transduction and Targeted Therapy · 2021
       
Manganese promotes α-synuclein amyloid aggregation through the induction of protein phase transition
Journal of Biological Chemistry · 2022
       
Biological colloids: Unique properties of membranelles organelles in the cell
Advances in Colloid and Interface Science · 2022
       
Electrostatically Driven Complex Coacervation and Amyloid Aggregation of Tau Are Independent Processes with Overlapping Conditions
ACS Chemical Neuroscience · 2020
       
Myricetin Inhibits α‐Synuclein Amyloid Aggregation by Delaying the Liquid‐to‐Solid Phase Transition
ChemBioChem · 2022
       
The ‘a, b, c’s of pretangle tau and their relation to aging and the risk of Alzheimer’s Disease
Seminars in Cell & Developmental Biology · 2021
       
Granulins modulate liquid–liquid phase separation and aggregation of the prion-like C-terminal domain of the neurodegeneration-associated protein TDP-43
Journal of Biological Chemistry · 2020
       
α‐Synuclein phase separation and amyloid aggregation are modulated by C‐terminal truncations
FEBS Letters · 2022
       
Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation
Biorxiv · 2019
       
The Role of Post-Translational Modifications in the Phase Transitions of Intrinsically Disordered Proteins
International Journal of Molecular Sciences · 2019
       
Tau liquid–liquid phase separation: At the crossroads of tau physiology and tauopathy
Journal of Cellular Physiology · 2022
       
Biomolecular condensates in neurodegeneration and cancer
Traffic · 2019
       
Liquid-liquid phase separation of tau driven by hydrophobic interaction facilitates fibrillization of tau
Biorxiv · 2020
       
Regulatory mechanisms of tau protein fibrillation under the conditions of liquid–liquid phase separation
Proceedings of the National Academy of Sciences · 2020
       
Physiological, Pathological, and Targetable Membraneless Organelles in Neurons
Trends in Neurosciences · 2019
       
Liquid–Liquid Phase Separation of Tau Protein Is Encoded at the Monomeric Level
The Journal of Physical Chemistry Letters · 2021
       
Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies
International Journal of Molecular Sciences · 2020
       
Liquid–liquid phase separation of tau: From molecular biophysics to physiology and disease
Protein Science · 2021
       
Camouflaged Fluorescent Silica Nanoparticles Target Aggregates and Condensates of the Amyloidogenic Protein Tau
Bioconjugate Chemistry · 2022
       
Biomolecular condensation of the microtubule-associated protein tau
Seminars in Cell & Developmental Biology · 2020
       
Melatonin: Regulation of Biomolecular Condensates in Neurodegenerative Disorders
Antioxidants · 2021
       
Zinc enhances liquid-liquid phase separation of Tau protein and aggravates mitochondrial damages in cells
International Journal of Biological Macromolecules · 2022
       
Regulation of Liquid-Liquid Phase Separation by Molecular Chaperones
Thermal Medicine · 2021
       
An interpretable machine learning algorithm to predict disordered protein phase separation based on biophysical interactions
N/A · 2022
       
Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets
Molecules · 2021
       
The effect of lipid composition on the dynamics of tau fibrils
Proteins: Structure, Function, and Bioinformatics · 2022
       
Temporal and spatial characterisation of protein liquid-liquid phase separation using NMR spectroscopy
Nature Communications · 2022
       
Driving tau into phase-separated liquid droplets
Journal of Biological Chemistry · 2019
       
Zn-dependent structural transition of SOD1 modulates its ability to undergo liquid-liquid phase separation
N/A · 2022
       
The contribution of electrostatics to hydrogen exchange in the unfolded protein state
Biorxiv · 2021
       
Contrasting Effects of Ferric and Ferrous Ions on Oligomerization and Droplet Formation of Tau: Implications in Tauopathies and Neurodegeneration
ACS Chemical Neuroscience · 2021
       
Liquid–Liquid Phase Separation and Its Mechanistic Role in Pathological Protein Aggregation
Journal of Molecular Biology · 2020
       
Tau Protein and Frontotemporal Dementias
Advances in Experimental Medicine and Biology · 2021
       
Tau proteinopathies and the prion concept
Progress in Molecular Biology and Translational Science · 2020
       
Spontaneous nucleation and fast aggregate-dependent proliferation of α-synuclein aggregates within liquid condensates at physiological pH
Biorxiv · 2021
       
Liquid-liquid phase separation and fibrillization of tau are independent processes with overlapping conditions
Biorxiv · 2019
       
Cellular Biology of Tau Diversity and Pathogenic Conformers
Frontiers in Neurology · 2020
       
Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation
Nature Communications · 2021
       
Mechanisms of secretion and spreading of pathological tau protein
Cellular and Molecular Life Sciences · 2019
       
Regulation of biomolecular condensate dynamics by signaling
Current Opinion in Cell Biology · 2021
       
Identification of synthetic inhibitors for the DNA binding of intrinsically disordered circadian clock transcription factors
Chemical Communications · 2020
       
Evaluation of Toxic Amyloid β42 Oligomers in Rat Primary Cerebral Cortex Cells and Human iPS-derived Neurons Treated with 10-Me-Aplog-1, a New PKC Activator
International Journal of Molecular Sciences · 2020
       
Liquid-Liquid Phase Separation of Tau Driven by Hydrophobic Interaction Facilitates Fibrillization of Tau
Journal of Molecular Biology · 2021
       
Label‐Free Quantitative Analysis of Coacervates via 3D Phase Imaging
Advanced Optical Materials · 2021
       
Tau conformers in FTLD-MAPT undergo liquid-liquid phase separation and perturb the nuclear envelope
Biorxiv · 2020
       
Interplay between tau and α‐synuclein liquid–liquid phase separation
Protein Science · 2021
       
Tau liquid–liquid phase separation in neurodegenerative diseases
Trends in Cell Biology · 2022
       
The structure and phase of tau: from monomer to amyloid filament
Cellular and Molecular Life Sciences · 2020