@article{Bothwell_2018,
title={Adaptive design clinical trials: a review of the literature and ClinicalTrials.gov},
volume={8},
ISSN={2044-6055},
url={http://dx.doi.org/10.1136/bmjopen-2017-018320},
DOI={10.1136/bmjopen-2017-018320},
number={2},
journal={BMJ Open},
publisher={BMJ},
author={Bothwell,
Laura E and Avorn,
Jerry and Khan,
Nazleen F and Kesselheim,
Aaron S},
year={2018},
month=feb,
pages={e018320} }