Authors:
Romain Lévy, Peng Zhang, Paul Bastard, Paul Bastard, Karim Dorgham, Isabelle Melki, Alice Hadchouel, George C. Hartoularos, Bénédicte Neven, Martin Castelle, Charlotte Roy, Tom Toin, Laureline Berteloot, Lucy Bizien, Hanène Abid, Marianne Burgard (...)
Romain Lévy, Peng Zhang, Paul Bastard, Paul Bastard, Karim Dorgham, Isabelle Melki, Alice Hadchouel, George C. Hartoularos, Bénédicte Neven, Martin Castelle, Charlotte Roy, Tom Toin, Laureline Berteloot, Lucy Bizien, Hanène Abid, Marianne Burgard, Nadhira Houhou-Fidouh, Flore Rozenberg, Emmanuelle Jouanguy, Emmanuelle Jouanguy, Chun Jimmie Ye, Guy Gorochov, Qian Zhang, Qian Zhang, Jean-Laurent Casanova, Jean-Laurent Casanova
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Abstract:
Significance Life-threatening COVID-19 pneumonia can be caused by rare inborn errors of type I interferon (IFN) immunity, or by autoantibodies neutralizing IFN-α2 or IFN-ω. In 2018, we reported a girl with critical influenza pneumonia due to inherited IRF9 deficiency, a component of the ISGF-3 transcription factor. We report the course of COVID-19 in the same patient. She was admitted on day 1 of upper respiratory tract infection with viremia. Administration of SARS-CoV-2–specific neutralizing monoclonal antibodies on day 2 prevented the de (...)
Significance Life-threatening COVID-19 pneumonia can be caused by rare inborn errors of type I interferon (IFN) immunity, or by autoantibodies neutralizing IFN-α2 or IFN-ω. In 2018, we reported a girl with critical influenza pneumonia due to inherited IRF9 deficiency, a component of the ISGF-3 transcription factor. We report the course of COVID-19 in the same patient. She was admitted on day 1 of upper respiratory tract infection with viremia. Administration of SARS-CoV-2–specific neutralizing monoclonal antibodies on day 2 prevented the development of pneumonia. SARS-CoV-2–specific monoclonal antibodies were sufficient to overcome a lack of ISGF-3– and IRF9-dependent type I and type III IFN immunity to the virus. They should be considered in selected children at high risk of life-threatening COVID-19.
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